95669-35-5|Wy 27127|N-[2-[[(2R,11bS)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-methylsulfonylamino]ethyl]methanesulfonamide|-范德生物科技公司

Wy 27127

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names：
N-[2-[[(2R,11bS)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-methylsulfonylamino]ethyl]methanesulfonamide
CAS号：
95669-35-5
MDL Number：
MF(分子式)： C17H27N3O4S2 MW(分子量)： 401.54
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	N-[2-[[(2R,11bS)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-methylsulfonylamino]ethyl]methanesulfonamide
英文别名	Wy 27127; Wy27127; Wy-27127
CAS号	95669-35-5
Inchi	InChI=1S/C17H27N3O4S2/c1-25(21,22)18-9-12-20(26(2,23)24)15-8-11-19-10-7-14-5-3-4-6-16(14)17(19)13-15/h3-6,15,17-18H,7-13H2,1-2H3/t15-,17+/m1/s1
InchiKey	VSQCTWPNMPWYSD-WBVHZDCISA-N
分子式 Formula	C17H27N3O4S2
分子量 Molecular Weight	401.54
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Wy 27127(CAS:95669-35-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Wy 27127 is an alpha 2-adrenoceptors antagonist that has estimated potency based on ability to block clonidine-induced inhibition of electrically-evoked contractions of the rat isolated vas deferens.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bill SJ, Boniface A, Haroun F, McAdams RP, Lattimer N, Rhodes KF. Some pharmacological properties of Wy 27127 a more selective alpha

2:alpha 1-adrenoceptor antagonist than idazoxan in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):418-22. PubMed PMID: 2881217.

[3]Blaxall HS, Murphy TJ, Baker JC, Ray C, Bylund DB. Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line. J Pharmacol Exp Ther. 1991 Oct;259(1):323-9. PubMed PMID: 1656026.

[4]Loomis CW, Arunachalam KD. Intrathecal St-587: effects on nociceptive reflexes and blood pressure in the rat. J Pharmacol Exp Ther. 1992 Nov;263(2):428-35. PubMed PMID: 1331398.

[5] Wy 27127: A Peripherally Acting Alpha-2 Adrenoceptor Antagonist: HARTLEY JE and FLETCHER A. Wyeth Research (UK) Ltd., Huntercombe Lane South, Taplow, Maidenhead, Berks. SL6 0PH. J Psychopharmacol. 1992 Jan;6(1):106. doi: 10.1177/026988119200600131. PubMed PMID: 22291259.

5: Rhodes KF, Waterfall JF. The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine. Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):261-8. PubMed PMID: 2884574.

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