80092-76-8|WR 243251|7-chloro-3-(2,4-dichlorophenyl)-1-[3-(dimethylamino)propylimino]-2,3,4,10-tetrahydroacridin-9-one|-范德生物科技公司

WR 243251

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names：
7-chloro-3-(2,4-dichlorophenyl)-1-[3-(dimethylamino)propylimino]-2,3,4,10-tetrahydroacridin-9-one
CAS号：
80092-76-8
MDL Number：
MF(分子式)： C24H24Cl3N3O MW(分子量)： 476.826
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	7-chloro-3-(2,4-dichlorophenyl)-1-[3-(dimethylamino)propylimino]-2,3,4,10-tetrahydroacridin-9-one
英文别名	WR 243251; WR243251; WR-243251
CAS号	80092-76-8
Inchi	InChI=1S/C24H24Cl3N3O/c1-30(2)9-3-8-28-21-10-14(17-6-4-16(26)13-19(17)27)11-22-23(21)24(31)18-12-15(25)5-7-20(18)29-22/h4-7,12-14H,3,8-11H2,1-2H3,(H,29,31)/b28-21+
InchiKey	QPVVEWNCFBEZTH-SGWCAAJKSA-N
分子式 Formula	C24H24Cl3N3O
分子量 Molecular Weight	476.826
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	WR 243251(CAS:80092-76-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	WR 243251 is a dihydroacridinedione with strong potential as a blood schizonticidal agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Dorn A, Scovill JP, Ellis WY, Matile H, Ridley RG, Vennerstrom JL. Short report: floxacrine analog WR 243251 inhibits hematin polymerization. Am J Trop Med Hyg. 2001 Jul;65(1):19-20. PubMed PMID: 11504401.

[2]Berman J, Brown L, Miller R, Andersen SL, McGreevy P, Schuster BG, Ellis W, Ager A, Rossan R. Antimalarial activity of WR 243251, a Dihydroacridinedione. Antimicrob Agents Chemother. 1994 Aug;38(8):1753-6. PubMed PMID: 7986005; PubMed Central PMCID: PMC284632.

[3] Milhous WK. Development of new drugs for chemoprophylaxis of malaria. Med Trop (Mars). 2001;61(1):48-50. Review. PubMed PMID: 11584654.

[4] Coleman RE, Polsa N, Eikarat N, Kollars TM Jr, Sattabongkot J. Prevention of sporogony of Plasmodium vivax in Anopheles dirus mosquitoes by transmission-blocking antimalarials. Am J Trop Med Hyg. 2001 Sep;65(3):214-8. PubMed PMID: 11561707.

[5] Coleman RE, Clavin AM, Milhous WK. Gametocytocidal and sporontocidal activity of antimalarials against Plasmodium berghei ANKA in ICR Mice and Anopheles stephensi mosquitoes. Am J Trop Med Hyg. 1992 Feb;46(2):169-82. PubMed PMID: 1539752.

6: Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships. J Med Chem. 2011 Jul 14;54(13):4399-426. doi: 10.1021/jm200015a. Epub 2011 Jun 16. PubMed PMID: 21630666.7: Milhous W. Development of new drugs for chemoprophylaxis of malaria. Bull Soc Pathol Exot. 2001 Jul;94(2 Pt 2):149-51. PubMed PMID: 16579068.8: Suswam E, Kyle D, Lang-Unnasch N. Plasmodium falciparum: the effects of atovaquone resistance on respiration. Exp Parasitol. 2001 Aug;98(4):180-7. PubMed PMID: 11560411.9: Kesten SJ, Degnan MJ, Hung J, McNamara DJ, Ortwine DF, Uhlendorf SE, Werbel LM. Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures. J Med Chem. 1992 Sep 18;35(19):3429-47. PubMed PMID: 1404226.

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