56973-41-2|Withanolide B|(5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione|-范德生物科技公司

Withanolide B

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names：
(5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione
CAS号：
56973-41-2
MDL Number：
MF(分子式)： C28H38O5 MW(分子量)： 454.607
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione
英文别名	Withanolide B
CAS号	56973-41-2
SMILES	CC(C[C@@H](O1)[C@@H](C)[C@H]([C@]2(CC[C@]3([H])[C@@]45C)C)CC[C@@]2([H])[C@]3([H])[C@]6([H])[C@](O6)([H])[C@@]5(O)CC=CC4=O)=C(C)C1=O
Inchi	InChI=1S/C28H38O5/c1-14-13-20(32-25(30)15(14)2)16(3)17-8-9-18-22-19(10-12-26(17,18)4)27(5)21(29)7-6-11-28(27,31)24-23(22)33-24/h6-7,16-20,22-24,31H,8-13H2,1-5H3/t16-,17+,18-,19-,20+,22-,23+,24+,26+,27-,28-/m0/s1
InchiKey	ZTEVDTFJUUJBLP-HGSBMKTESA-N
分子式 Formula	C28H38O5
分子量 Molecular Weight	454.607
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Withanolide B(CAS:56973-41-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B was identified as a neuronal nitric oxide synthase (nNOS) inhibitor that also inhibited inducible NOS (iNOS) and endothelial NOS and as a ligand for the PARP1 catalytic domain.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ben Bakrim W, El Bouzidi L, Nuzillard JM, Cretton S, Saraux N, Monteillier A, Christen P, Cuendet M, Bekkouche K. Bioactive metabolites from the leaves of Withania adpressa. Pharm Biol. 2018 Dec;56(1):505-510. doi: 10.1080/13880209.2018.149978[1]PubMed PMID: 30451050; PubMed Central PMCID: PMC6249549.

[2]Dubey S, Kallubai M, Sarkar A, Subramanyam R. Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin. PLoS One. 2018 Nov 7;13(11):e0200053. doi: 10.1371/journal.pone.0200053. eCollection 2018. PubMed PMID: 30403672; PubMed Central PMCID: PMC6221254.

[3] Hussain H, Csuk R, Green IR, Ur Rehman N, Abbas G, Hussain W. Journey Describing the Cytotoxic Potential of Withanolides: A Patent Review. Recent Pat Anticancer Drug Discov. 2018;13(4):411-421. doi: 10.2174/1574892813666180808154928. Review. PubMed PMID: 30091418.

[4] Mishra A, Singh SP, Mahfooz S, Bhattacharya A, Mishra N, Shirke PA, Nautiyal CS. Bacterial endophytes modulates the withanolide biosynthetic pathway and physiological performance in Withania somnifera under biotic stress. Microbiol Res. 2018 Jul - Aug;212-21

[5]17-28. doi: 10.1016/j.micres.2018.04.006. Epub 2018 Apr 22. PubMed PMID: 29853165.

5: Yang L, Meng X, Kuang H. Comparisons of the pharmacokinetic and tissue distribution profiles of withanolide B after intragastric administration of the effective part of Datura metel L. in normal and psoriasis guinea pigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;108

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