205381-53-9|WC-9|1-Phenoxy-4-(2-thiocyanato-ethoxy)-benzene|-范德生物科技公司

WC-9

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names：
1-Phenoxy-4-(2-thiocyanato-ethoxy)-benzene
CAS号：
205381-53-9
MDL Number：
MF(分子式)： C15H13NO2S MW(分子量)： 271.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	1-Phenoxy-4-(2-thiocyanato-ethoxy)-benzene
英文别名	WC-9; WC 9; WC9;
CAS号	205381-53-9
Inchi	InChI=1S/C15H13NO2S/c16-12-19-11-10-17-13-6-8-15(9-7-13)18-14-4-2-1-3-5-14/h1-9H,10-11H2
InchiKey	YQZHGQYIMXWEHI-UHFFFAOYSA-N
分子式 Formula	C15H13NO2S
分子量 Molecular Weight	271.33
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	WC-9(CAS:205381-53-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	WC-9 is a squalene synthase (SQS) inhibitor that acts by binding to TcSQS and HsSQS.
Application1
Application2
Application3

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危险性	Warning
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备注

[1]Peltzer K, Pengpid S. The Association of Dietary Behaviors and Physical Activity Levels with General and Central Obesity among ASEAN University Students. AIMS Public Health. 2017 Jun 23;4(3):301-313. doi: 10.3934/publichealth.2017.3.30[1]eCollection 2017. PubMed PMID: 29546219; PubMed Central PMCID: PMC5690456.

[2]Chao MN, Storey M, Li C, Rodríguez MG, Di Salvo F, Szajnman SH, Moreno SNJ, Docampo R, Rodriguez JB. Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation. Bioorg Med Chem. 2017 Dec 15;25(24):6435-6449. doi: 10.1016/j.bmc.2017.10.016. Epub 2017 Oct 16. PubMed PMID: 29107437.

[3] Chao MN, Li C, Storey M, Falcone BN, Szajnman SH, Bonesi SM, Docampo R, Moreno SN, Rodriguez JB. Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem. 2016 Dec 16;11(24):2690-2702. doi: 10.1002/cmdc.201600505. Epub 2016 Nov 25. PubMed PMID: 27886451; PubMed Central PMCID: PMC5200956.

[4] Vadiveloo M, Sacks FM, Champagne CM, Bray GA, Mattei J. Greater Healthful Dietary Variety Is Associated with Greater 2-Year Changes in Weight and Adiposity in the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) Trial. J Nutr. 2016 Aug;146(8):1552-9. doi: 10.3945/jn.115.224683. Epub 2016 Jun 29. PubMed PMID: 27358422; PubMed Central PMCID: PMC4958287.

[5] Rodriguez JB. WC-9 a Lead Drug with Great Prospects for American Trypanosomiasis and Toxoplasmosis. Mini Rev Med Chem. 2016;16(15):1195-1200. Review. PubMed PMID: 27290911.

6: Feyereisen GW, Moorman TB, Christianson LE, Venterea RT, Coulter JA, Tschirner UW. Performance of Agricultural Residue Media in Laboratory Denitrifying Bioreactors at Low Temperatures. J Environ Qual. 2016 May;45(3):779-87. doi: 10.2134/jeq2015.07.0407. PubMed PMID: 27136142.7: Colangelo LA, Vu TH, Szklo M, Burke GL, Sibley C, Liu K. Is the association of hypertension with cardiovascular events stronger among the lean and normal weight than among the overweight and obese? The multi-ethnic study of atherosclerosis. Hypertension. 2015 Aug;66(2):286-93. doi: 10.1161/HYPERTENSIONAHA.114.04863. Epub 2015 Jun 15. PubMed PMID: 26077561; PubMed Central PMCID: PMC4828916.8: Chao MN, Matiuzzi CE, Storey M, Li C, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB. Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem. 2015 Jun;10(6):1094-108. doi: 10.1002/cmdc.201500100. Epub 2015 Apr 27. PubMed PMID: 25914175; PubMed Central PMCID: PMC4447534.9: Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, de Carvalho TM, de Souza W, Urbina JA, Wang AH, Docampo R, Li K, Liu YL, Oldfield E, Guo RT. Squalene synthase as a target for Chagas disease therapeutics. PLoS Pathog. 2014 May 1;10(5):e1004114. doi: 10.1371/journal.ppat.1004114. eCollection 2014 May. Erratum in: PLoS Pathog. 2014 Jun;10(6):e1004239. PubMed PMID: 24789335; PubMed Central PMCID: PMC4006925.10: Manipadam MT, Bhagat SK, Gopalakrishnan G, Kekre NS, Chacko NK, Prasanna S. Warty carcinoma of the penis: A clinicopathological study from South India. Indian J Urol. 2013 Oct;29(4):282-7. doi: 10.4103/0970-1591.120106. PubMed PMID: 24235788; PubMed Central PMCID: PMC3822342.1

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