75808-67-2|VV-Hemorphin-7|L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine|-范德生物科技公司

VV-Hemorphin-7

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names：
L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine
CAS号：
75808-67-2
MDL Number：
MF(分子式)： C59H82N14O13 MW(分子量)： 1195.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine
英文别名	VV-Hemorphin-7; Val-val-tyr-pro-trp-thr-gln-arg-phe;
CAS号	75808-67-2
Inchi	InChI=1S/C59H82N14O13/c1-31(2)47(61)54(81)71-48(32(3)4)55(82)69-43(27-35-19-21-37(75)22-20-35)57(84)73-26-12-18-45(73)53(80)68-42(29-36-30-65-39-16-10-9-15-38(36)39)52(79)72-49(33(5)74)56(83)67-41(23-24-46(60)76)51(78)66-40(17-11-25-64-59(62)63)50(77)70-44(58(85)86)28-34-13-7-6-8-14-34/h6-10,13-16,19-22,30-33,40-45,47-49,65,74-75H,11-12,17-18,23-29,61H2,1-5H3,(H2,60,76)(H,66,78)(H,67,83)(H,68,80)(H,69,82)(H,70,77)(H,71,81)(H,72,79)(H,85,86)(H4,62,63,64)/t33-,40+,41+,42+,43+,44+,45+,47+,48+,49+/m1/s1
InchiKey	FFBBHLKDMHCFTH-AKYHLAPZSA-N
分子式 Formula	C59H82N14O13
分子量 Molecular Weight	1195.39
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	VV-Hemorphin-7(CAS:75808-67-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	VV-Hemorphin-7 is a morphinomimetic peptide.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Fruitier I, Garreau I, Piot JM. Cathepsin D is a good candidate for the specific release of a stable hemorphin from hemoglobin in vivo: VV-hemorphin-7. Biochem Biophys Res Commun. 1998 May 29;246(3):719-24. PubMed PMID: 9618278.

[2]Maraninchi M, Feron D, Fruitier-Arnaudin I, Bégu-Le Corroller A, Nogueira JP, Mancini J, Valéro R, Piot JM, Vialettes B. Serum hemorphin-7 levels are decreased in obesity. Obesity (Silver Spring). 2013 Feb;21(2):378-81. doi: 10.1002/oby.20280. PubMed PMID: 23532992.

[3] Desiderio C, D'Angelo L, Rossetti DV, Iavarone F, Giardina B, Castagnola M, Massimi L, Tamburrini G, Di Rocco C. Cerebrospinal fluid top-down proteomics evidenced the potential biomarker role of LVV- and VV-hemorphin-7 in posterior cranial fossa pediatric brain tumors. Proteomics. 2012 Jul;12(13):2158-66. doi: 10.1002/pmic.201100499. Epub 2012 Jun 18. PubMed PMID: 22623401.

[4] Dagouassat N, Garreau I, Sannier F, Zhao Q, Piot JM. Generation of VV-hemorphin-7 from globin by peritoneal macrophages. FEBS Lett. 1996 Mar 11;382(1-2):37-42. PubMed PMID: 8612760.

[5] Dagouassat N, Garreau I, Zhao Q, Sannier F, Piot JM. Kinetic of in vitro generation of some hemorphins: early release of LVV-hemorphin-7, precursor of VV-hemorphin-7. Neuropeptides. 1996 Feb;30(1):1-5. PubMed PMID: 8868292.

6: Garreau I, Zhao Q, Pejoan C, Cupo A, Piot JM. VV-hemorphin-7 and LVV-hemorphin-7 released during in vitro peptic hemoglobin hydrolysis are morphinomimetic peptides. Neuropeptides. 1995 Apr;28(4):243-50. PubMed PMID: 7596489.7: Szikra J, Benyhe S, Orosz G, Darula Z, Piot JM, Fruitier I, Monory K, Hanoune J, Borsodi A. Radioligand binding properties of VV-hemorphin 7, an atypical opioid peptide. Biochem Biophys Res Commun. 2001 Mar 2;281(3):670-7. PubMed PMID: 11237710.8: Cohen M, Fruitier-Arnaudin I, Sauvan R, Birnbaum D, Piot JM. Serum levels of Hemorphin-7 peptides in patients with breast cancer. Clin Chim Acta. 2003 Nov;337(1-2):59-67. PubMed PMID: 14568181.9: Yatskin ON, Philippova MM, Blishchenko EYu, Karelin AA, Ivanov VT. LVV- and VV-hemorphins: comparative levels in rat tissues. FEBS Lett. 1998 May 29;428(3):286-90. PubMed PMID: 9654150.10: Lammerich HP, Busmann A, Kutzleb C, Wendland M, Seiler P, Berger C, Eickelmann P, Meyer M, Forssmann WG, Maronde E. Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3. Br J Pharmacol. 2003 Apr;138(8):1431-40. PubMed PMID: 12721098; PubMed Central PMCID: PMC1573796.1

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