73621-92-8|Viprostol|Prosta-5,13-dien-1-oic acid, 16-ethenyl-11,16-dihydroxy-9-oxo-, methyl ester, (5Z,11alpha,13E)-|-范德生物科技公司

Viprostol

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names：
Prosta-5,13-dien-1-oic acid, 16-ethenyl-11,16-dihydroxy-9-oxo-, methyl ester, (5Z,11alpha,13E)-
CAS号：
73621-92-8
MDL Number：
MF(分子式)： C23H36O5 MW(分子量)： 392.536
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Prosta-5,13-dien-1-oic acid, 16-ethenyl-11,16-dihydroxy-9-oxo-, methyl ester, (5Z,11alpha,13E)-
英文别名	Viprostol; CL 115,347
CAS号	73621-92-8
Inchi	InChI=1S/C23H36O5/c1-4-6-15-23(27,5-2)16-11-13-19-18(20(24)17-21(19)25)12-9-7-8-10-14-22(26)28-3/h5,7,9,11,13,18-19,21,25,27H,2,4,6,8,10,12,14-17H2,1,3H3/b9-7-,13-11+/t18-,19-,21-,23?/m1/s1
InchiKey	TWCQWABAGCMHLL-ROVQGQOSSA-N
分子式 Formula	C23H36O5
分子量 Molecular Weight	392.536
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Viprostol(CAS:73621-92-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Viprostol is a prostaglandin antihypertensive.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Chan PS, Cervoni P, Scully PA, Ronsberg MA, Accomando RC. Mechanism of action of a new prostaglandin antihypertensive, viprostol [CL 115 347; (dl)-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl-prostaglandin E2 methyl ester]: (I). Vasodilation. J Hypertens. 1986 Dec;4(6):741-7. PubMed PMID: 3029218.

[2]Chan PS, Cervoni P, Accomando RC, Quirk GJ, Ronsberg MA. Mechanism of action of a new prostaglandin antihypertensive, viprostol [CL 115 347; (dl)-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl-prostaglandin E2 methyl ester]: (II). Effects on the adrenergic nervous system. J Hypertens. 1986 Dec;4(6):749-57. PubMed PMID: 2880911.

[3] Olsen EA, DeLong E. Transdermal viprostol in the treatment of male pattern baldness. J Am Acad Dermatol. 1990 Sep;23(3 Pt 1):470-2. PubMed PMID: 2212146.

[4] Nicolau G, Cosulich DB, Tonelli A, Chen SM, Pruzinsky MS, Blum D. Metabolism of viprostol--a synthetic vasodilator PGE2 analog. Prostaglandins. 1986 Apr;31(4):811-27. PubMed PMID: 3088678.

[5] Cervoni P, Chan PS. Synthetic stable orally and transdermally long-acting prostaglandin E2 (PGE2) congener (viprostol; CL 115,347) and prostacyclin congener (CL 115,999) as antihypertensive agents. Adv Prostaglandin Thromboxane Leukot Res. 1989;19:331-4. PubMed PMID: 2526492.

6: Olivari MT, Levine TB, Cohn JN. Evidence for a direct renal stimulating effect of prostaglandin E2 on renin release in patients with congestive heart failure. Circulation. 1986 Dec;74(6):1203-7. PubMed PMID: 3536150.7: Belch JJ, O'Dowd A, Forbes CD, Sturrock RD. Platelet sensitivity to a prostacyclin analogue in systemic sclerosis. Br J Rheumatol. 1985 Nov;24(4):346-50. PubMed PMID: 2415199.8: Lai FM, Tanikella TK, Cervoni P. The vasorelaxant effect of (+/-)-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl-prostaglandin E2 (CL 115, 129) and its methyl ester (CL 115, 347) on the isolated ductus arteriosus preparation. Life Sci. 1984 May 7;34(19):1861-6. PubMed PMID: 6588286.9: Lai FM, Cobuzzi A, Tanikella T, Cervoni P. Relaxant actions of viprostol and prostaglandin E2 on tracheal muscle and their effects on calcium influx. Prostaglandins. 1988 Jul;36(1):115-23. PubMed PMID: 3175022.10: Chatziantoniou C, Arendshorst WJ. Prostaglandin interactions with angiotensin, norepinephrine, and thromboxane in rat renal vasculature. Am J Physiol. 1992 Jan;262(1 Pt 2):F68-76. PubMed PMID: 1733298.1

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