52435-65-1|Valyl adenylate|(S)-2-amino-3-methylbutanoic (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride|-范德生物科技公司

Valyl adenylate

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names：
(S)-2-amino-3-methylbutanoic (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride
CAS号：
52435-65-1
MDL Number：
MF(分子式)： C15H23N6O8P MW(分子量)： 446.35
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-2-amino-3-methylbutanoic (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride
英文别名	Valyl adenylate; Valyl-adenylate; Valyladenylate;
CAS号	52435-65-1
Inchi	InChI=1S/C15H23N6O8P/c1-6(2)8(16)15(24)29-30(25,26)27-3-7-10(22)11(23)14(28-7)21-5-20-9-12(17)18-4-19-13(9)21/h4-8,10-11,14,22-23H,3,16H2,1-2H3,(H,25,26)(H2,17,18,19)/t7-,8+,10-,11-,14-/m1/s1
InchiKey	KAVINRUMCQFLGF-NIXGFCADSA-N
分子式 Formula	C15H23N6O8P
分子量 Molecular Weight	446.35
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Valyl adenylate(CAS:52435-65-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Valyl adenylate is a peptide.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Jakubowski H. Yellow lupin (Lupinus luteus) aminoacyl-tRNA synthetases. Isolation and some properties of enzyme-bound valyl adenylate and seryl adenylate. Biochim Biophys Acta. 1978 Dec 21;521(2):584-96. PubMed PMID: 32907.

[2]Hountondji C, Lazennec C, Beauvallet C, Dessen P, Pernollet JC, Plateau P, Blanquet S. Crucial role of conserved lysine 277 in the fidelity of tRNA aminoacylation by Escherichia coli valyl-tRNA synthetase. Biochemistry. 2002 Dec 17;41(50):14856-65. PubMed PMID: 12475234.

[3] Silvian LF, Wang J, Steitz TA. Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. Science. 1999 Aug 13;285(5430):1074-7. PubMed PMID: 10446055.

[4] Southgate CC, Dixon HB. Phosphonate analogues of aminoacyl adenylates. Biochem J. 1978 Nov 1;175(2):461-5. PubMed PMID: 743207; PubMed Central PMCID: PMC1186092.

[5] Dulic M, Perona JJ, Gruic-Sovulj I. Determinants for tRNA-dependent pretransfer editing in the synthetic site of isoleucyl-tRNA synthetase. Biochemistry. 2014 Oct 7;53(39):6189-98. doi: 10.1021/bi5007699. Epub 2014 Sep 23. PubMed PMID: 25207837; PubMed Central PMCID: PMC4188249.

6: Jakubowski H. The mechanism of inhibition of valyl-tRNA synthetase by S-adenosylhomocysteine. Biochim Biophys Acta. 1982 Dec 20;709(2):325-31. PubMed PMID: 7150609.7: Fersht AR, Kaethner MM. Enzyme hyperspecificity. Rejection of threonine by the valyl-tRNA synthetase by misacylation and hydrolytic editing. Biochemistry. 1976 Jul 27;15(15):3342-6. PubMed PMID: 182209.8: Nordin BE, Schimmel P. Transiently misacylated tRNA is a primer for editing of misactivated adenylates by class I aminoacyl-tRNA synthetases. Biochemistry. 2003 Nov 11;42(44):12989-97. PubMed PMID: 14596614.9: Dulic M, Cvetesic N, Perona JJ, Gruic-Sovulj I. Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases. J Biol Chem. 2010 Jul 30;285(31):23799-809. doi: 10.1074/jbc.M110.133553. Epub 2010 May 24. PubMed PMID: 20498377; PubMed Central PMCID: PMC2911327.10: Fukunaga R, Yokoyama S. Structural basis for substrate recognition by the editing domain of isoleucyl-tRNA synthetase. J Mol Biol. 2006 Jun 16;359(4):901-12. Epub 2006 Apr 25. PubMed PMID: 16697013.1

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