651331-92-9|UR-1505|2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid|-范德生物科技公司

UR-1505

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names：
2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid
CAS号：
651331-92-9
MDL Number：
MF(分子式)： C10H7F5O4 MW(分子量)： 286.154
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid
英文别名	UR-1505, UR1505, UR 1505
CAS号	651331-92-9
Inchi	InChI=1S/C10H7F5O4/c11-9(12,10(13,14)15)4-19-5-1-2-6(8(17)18)7(16)3-5/h1-3,16H,4H2,(H,17,18)
InchiKey	BLEWPNAUDGZWPU-UHFFFAOYSA-N
分子式 Formula	C10H7F5O4
分子量 Molecular Weight	286.154
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	UR-1505(CAS:651331-92-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	UR-1505 is a nuclear factor of activated T cells (NF-AT) inhibitor potentially for the treatment of atopic dermatitis. UR-1505 acts by means of a specific mechanism inhibiting T cell activation depending on T cell receptor signaling pathway. Furthermore, the antiproliferative effects of UR-1505 are not a consequence of decreased cell viability.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Vives R, Pontes C, Sarasa M, Millier A. Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial. Clin Ther. 2015 Sep 1;37(9):1955-65. doi: 10.1016/j.clinthera.2015.06.005. PubMed PMID: 26163200.

[2]Román J, de Arriba AF, Barrón S, Michelena P, Giral M, Merlos M, Bailón E, Comalada M, Gálvez J, Zarzuelo A, Ramis I. UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells. Mol Pharmacol. 2007 Aug;72(2):269-79. PubMed PMID: 17475810.

[3] Bailón E, Román J, Ramis I, Michelena P, Balsa D, Merlos M, Zarzuelo A, Gálvez J, Comalada M. The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis. J Pharmacol Sci. 2009 Feb;109(2):315-8. PubMed PMID: 19234369.

[4] Bailón E, Comalada M, Román J, Michelena P, Ramis I, Merlos M, Nieto A, Concha A, Zarzuelo A, Gálvez J. UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis. Inflamm Bowel Dis. 2008 Jul;14(7):888-97. doi: 10.1002/ibd.20381. PubMed PMID: 18253952.

[5] Bailón E, Camuesco D, Nieto A, Concha A, Fernández de Arriba A, Román J, Ramis I, Merlos M, Zarzuelo A, Gálvez J, Comalada M. The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition. Biochem Pharmacol. 2007 Nov 15;74(10):1496-506. PubMed PMID: 17720145.

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