344768-30-5|UBP141|(2R,3S)-1-[(phenanthren-3-yl)carbonyl]piperazine-2,3-dicarboxylic acid|-范德生物科技公司

UBP141

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names：
(2R,3S)-1-[(phenanthren-3-yl)carbonyl]piperazine-2,3-dicarboxylic acid
CAS号：
344768-30-5
MDL Number：
MF(分子式)： C21H18N2O5 MW(分子量)： 378.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(2R,3S)-1-[(phenanthren-3-yl)carbonyl]piperazine-2,3-dicarboxylic acid
英文别名	UBP141, UBP 141, UBP-141
CAS号	344768-30-5
SMILES	O=C([C@@H]1N(C(C2=CC=C3C=CC4=CC=CC=C4C3=C2)=O)CCN[C@@H]1C(O)=O)O
Inchi	InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-8-7-13-6-5-12-3-1-2-4-15(12)16(13)11-14/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m0/s1
InchiKey	VVUAQPXBYDYTDF-ZWKOTPCHSA-N
分子式 Formula	C21H18N2O5
分子量 Molecular Weight	378.38
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	UBP141(CAS:344768-30-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	UBP141 is a N-methyl-D-aspartate (NMDA) receptor antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Yamamoto H, Kamegaya E, Sawada W, Hasegawa R, Yamamoto T, Hagino Y, Takamatsu Y, Imai K, Koga H, Mishina M, Ikeda K. Involvement of the N-methyl-D-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity. Mol Brain. 2013 Dec 16;

6:56. doi: 10.1186/1756-6606-6-56. PubMed PMID: 24330819; PubMed Central PMCID: PMC3878647.

[3]Wang M, Chazot PL, Ali S, Duckett SF, Obrenovitch TP. Effects of NMDA receptor antagonists with different subtype selectivities on retinal spreading depression. Br J Pharmacol. 2012 Jan;165(1):235-44. doi: 10.1111/j.1476-5381.2011.01553.x. PubMed PMID: 21699507; PubMed Central PMCID: PMC3252980.

[4]Palygin O, Lalo U, Pankratov Y. Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes. Br J Pharmacol. 2011 Aug;163(8):1755-66. doi: 10.1111/j.1476-5381.2011.01374.x. PubMed PMID: 21449975; PubMed Central PMCID: PMC3166701.

[5] Palygin O, Lalo U, Verkhratsky A, Pankratov Y. Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes. Cell Calcium. 2010 Oct;48(4):225-31. doi: 10.1016/j.ceca.2010.09.004. PubMed PMID: 20926134.

5: Suárez F, Zhao Q, Monaghan DT, Jane DE, Jones S, Gibb AJ. Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones. Eur J Neurosci. 2010 Aug;32(3):359-67. doi: 10.1111/j.1460-9568.2010.07298.x. Epub 2010 Jul 6. PubMed PMID: 20618827; PubMed Central PMCID: PMC4177768.

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