101222-80-4|U 71184|N-[2-[(12S)-3-Methyl-7-oxo-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),3,8-triene-10-carbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide|-范德生物科技公司

U 71184

NMR下载 COA and HPLC MSDS下载
names：
N-[2-[(12S)-3-Methyl-7-oxo-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),3,8-triene-10-carbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide
CAS号：
101222-80-4
MDL Number：
MF(分子式)： C30H23N5O3 MW(分子量)： 501.546
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	N-[2-[(12S)-3-Methyl-7-oxo-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),3,8-triene-10-carbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide
英文别名	U 71184; U71184; U-71184
CAS号	101222-80-4
SMILES	O=C(C(N1)=CC2=C1C=CC=C2)NC3=CC4=C(NC(C(N(C[C@@]5([H])C6)C(C56C7=C8NC=C7C)=CC8=O)=O)=C4)C=C3
Inchi	InChI=1S/C30H23N5O3/c1-15-13-31-27-24(36)11-25-30(26(15)27)12-18(30)14-35(25)29(38)23-10-17-8-19(6-7-21(17)34-23)32-28(37)22-9-16-4-2-3-5-20(16)33-22/h2-11,13,18,31,33-34H,12,14H2,1H3,(H,32,37)/t18-,30?/m1/s1
InchiKey	KSEVSZOOMUWSRV-VITKDRCNSA-N
分子式 Formula	C30H23N5O3
分子量 Molecular Weight	501.546
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	U 71184(CAS:101222-80-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	U 71184 is an anti-tumor agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Gambari R, Bianchi N, Passadore M, Ambrosino P, Mongelli N, Cozzi P, Geroni C. Synthesis, cytotoxicity, antitumor activity and sequence selective binding of two pyrazole analogs structurally related to the antitumor agents U-71,184 and adozelesin. Anticancer Drug Des. 1997 Oct;12(7):555-76. PubMed PMID: 9365502.

[2]Passadore M, Bianchi N, Feriotto G, Mischiati C, Rutigliano C, Gambari R. In vitro and in vivo binding of a CC-1065 analogue to human gene sequences: a polymerase-chain reaction study. Eur J Pharmacol. 1997 Jan 29;319(2-3):317-25. PubMed PMID: 9042607.

[3] Kim DY, Shih DS, Cho DY, Swenson DH. Helix-stabilizing compounds CC-1065 and U-71,184 bind to RNA-DNA and DNA-DNA duplexes containing modified internucleotide linkages and stabilize duplexes against thermal melting. Antisense Res Dev. 1995 Spring;5(1):49-57. PubMed PMID: 7542048.

[4] Mohamadi F, Spees MM, Staten GS, Marder P, Kipka JK, Johnson DA, Boger DL, Zarrinmayeh H. Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits. J Med Chem. 1994 Jan 21;37(2):232-9. PubMed PMID: 8295210.

[5] Lee S, Inselburg J. In vitro sensitivity of Plasmodium falciparum to drugs that bind DNA or inhibit its synthesis. J Parasitol. 1993 Oct;79(5):780-2. PubMed PMID: 8410555.

6: Moy BC, Petzold GL, Badiner GJ, Kelly RC, Aristoff PA, Adams EG, Li LH, Bhuyan BK. Characterization of B16 melanoma cells resistant to the CC-1065 analogue U-71,184. Cancer Res. 1990 Apr 15;50(8):2485-92. PubMed PMID: 2317831.7: Swenson DH, Petzold GL, Williams MG, Li LH, Prairie MD, Krueger WC. Evaluation of DNA binding characteristics of some CC-1065 analogs. Chem Biol Interact. 1988;67(3-4):199-213. PubMed PMID: 3191534.8: Adams EG, Badiner GJ, Bhuyan BK. Effects of U-71,184 and several other CC-1065 analogues on cell survival and cell cycle of Chinese hamster ovary cells. Cancer Res. 1988 Jan 1;48(1):109-16. PubMed PMID: 2446739.

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