87302-57-6|Tylophorinicine|Dibenzo(f,H)pyrrolo(1,2-b)isoquinolin-14-ol, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (13aS,14R)-|-范德生物科技公司

Tylophorinicine

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names：
Dibenzo(f,H)pyrrolo(1,2-b)isoquinolin-14-ol, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (13aS,14R)-
CAS号：
87302-57-6
MDL Number：
MF(分子式)： C24H27NO5 MW(分子量)： 409.48
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Dibenzo(f,H)pyrrolo(1,2-b)isoquinolin-14-ol, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (13aS,14R)-
英文别名	Tylophorinicine; (+)-Tylophorinicine; DCB-3501;
CAS号	87302-57-6
Inchi	InChI=1S/C24H27NO5/c1-27-19-8-13-14-9-20(28-2)22(30-4)11-16(14)23-17(15(13)10-21(19)29-3)12-25-7-5-6-18(25)24(23)26/h8-11,18,24,26H,5-7,12H2,1-4H3/t18-,24-/m0/s1
InchiKey	JWHWLMNMGLICQZ-UUOWRZLLSA-N
分子式 Formula	C24H27NO5
分子量 Molecular Weight	409.48
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Tylophorinicine(CAS:87302-57-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Tylophorinicine a potential leukemic drug. It has Antifungal activity, inhibition of thymidylate synthase by pergularinine.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Gantait S, Kundu S. Neoteric trends in tissue culture-mediated biotechnology of Indian ipecac [Tylophora indica (Burm. f.) Merrill]. 3 Biotech. 2017 Jul;7(3):23[1]doi: 10.1007/s13205-017-0865-8. Epub 2017 Jul 6. Review. PubMed PMID: 28685479; PubMed Central PMCID: PMC5500466.

[2]Dhiman M, Parab RR, Manju SL, Desai DC, Mahajan GB. Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine. Nat Prod Commun. 2012 Sep;7(9):1171-2. PubMed PMID: 23074899.

[3] Liu Y, Liu J, Yu SS, Huang XZ, Hu YC. [Studies on chemical constituents of Cynanchum forrestii]. Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(6):500-3. Chinese. PubMed PMID: 17552154.

[4] Gao W, Bussom S, Grill SP, Gullen EA, Hu YC, Huang X, Zhong S, Kaczmarek C, Gutierrez J, Francis S, Baker DC, Yu S, Cheng YC. Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4338-42. Epub 2007 May 16. PubMed PMID: 17531481.

[5] Huang X, Gao S, Fan L, Yu S, Liang X. Cytotoxic alkaloids from the roots of Tylophora atrofolliculata. Planta Med. 2004 May;70(5):441-5. PubMed PMID: 15124090.

6: Ganguly T, Sainis KB. Inhibition of cellular immune responses by Tylophora indica in experimental models. Phytomedicine. 2001 Sep;8(5):348-55. PubMed PMID: 11695877.7: Rao KN, Bhattacharya RK, Veankatachalam SR. Inhibition of thymidylate synthase by pergularinine, tylophorinidine and deoxytubulosine. Indian J Biochem Biophys. 1999 Dec;36(6):442-8. PubMed PMID: 10844999.8: Rao KN, Venkatachalam SR. Inhibition of dihydrofolate reductase and cell growth activity by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine: the in vitro cytotoxicity of these plant alkaloids and their potential as antimicrobial and anticancer agents. Toxicol In Vitro. 2000 Feb;14(1):53-9. PubMed PMID: 10699361.9: Narasimha Rao K, Bhattacharya RK, Venkatachalam SR. Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine. Cancer Lett. 1998 Jun 19;128(2):183-8. Erratum in: Cancer Lett 1998 Dec 11;134(1):119. PubMed PMID: 9683281.10: Rao KN, Bhattacharya RK, Venkatachalam SR. Inhibition of thymidylate synthase and cell growth by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine. Chem Biol Interact. 1997 Oct 24;106(3):201-12. PubMed PMID: 9413547.1

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