160677-67-8|Tresperimus|2-((6-guanidinohexyl)amino)-2-oxoethyl (4-((3-aminopropyl)amino)butyl)carbamate|-范德生物科技公司

Tresperimus

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names：
2-((6-guanidinohexyl)amino)-2-oxoethyl (4-((3-aminopropyl)amino)butyl)carbamate
CAS号：
160677-67-8
MDL Number：
MF(分子式)： C17H37N7O3 MW(分子量)： 387.52
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	2-((6-guanidinohexyl)amino)-2-oxoethyl (4-((3-aminopropyl)amino)butyl)carbamate
英文别名	Tresperimus; LF-08-0299; LF 08-0299; LF08-0299;
CAS号	160677-67-8
Inchi	InChI=1S/C17H37N7O3/c18-8-7-10-21-9-5-6-13-24-17(26)27-14-15(25)22-11-3-1-2-4-12-23-16(19)20/h21H,1-14,18H2,(H,22,25)(H,24,26)(H4,19,20,23)
InchiKey	LVBMFPUTQOHXQE-UHFFFAOYSA-N
分子式 Formula	C17H37N7O3
分子量 Molecular Weight	387.52
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Tresperimus(CAS:160677-67-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Tresperimus induces tolerance after short-term treatment in a fully major histocompatibility mismatched rat cardiac allograft model.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bousquet E, Camelo S, Leroux les Jardins G, Goldenberg B, Naud MC, Besson-Lescure B, Lebreton L, Annat J, Behar-Cohen F, de Kozak Y. Protective effect of intravitreal administration of tresperimus, an immunosuppressive drug, on experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci. 2011 Jul 20;52(8):5414-23. doi: 10.1167/iovs.10-6740. PubMed PMID: 21666239.

[2]Simpson D. Tresperimus: a new agent for transplant tolerance induction. Expert Opin Investig Drugs. 2001 Jul;10(7):1381-6. Review. PubMed PMID: 11772258.

[3] el Marsafy S, Dutartre P, Gluckman E. Effect of tresperimus on ex vivo expansion of CD34+CD38(-)-enriched cord blood cells. Haematologia (Budap). 2002;32(4):327-36. PubMed PMID: 12803107.

[4] Claud P, Artur Y, Guichard JP, Laine R. Metabolism of tresperimus by rat aorta semicarbazide-sensitive amine oxidase (SSAO). Fundam Clin Pharmacol. 2002 Dec;16(6):461-70. PubMed PMID: 12685504.

[5] Claud P, Artur Y, Laine R. In vitro metabolism of tresperimus by human vascular semicarbazide-sensitive amine oxidase. Drug Metab Dispos. 2002 Jun;30(6):747-55. PubMed PMID: 12019205.

6: El Marsafy S, Dutartre P, Gluckman E. Effect of tresperimus on in vitro human cord blood CD34+ cell differentiation. Haematologia (Budap). 2001;31(2):139-46. PubMed PMID: 11583025.7: Claud P, Padovani P, Guichard JP, Artur Y, Lainé R. Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat. Drug Metab Dispos. 2001 May;29(5):735-41. PubMed PMID: 11302941.8: Elices MJ. Tresperimus (Laboratoires Fournier). Curr Opin Investig Drugs. 2001 Mar;2(3):372-4. PubMed PMID: 11575707.9: Komesli S, Dumas C, Dutartre P. Analysis of in vivo immunosuppressive and in vitro interaction with constitutive heat shock protein 70 activity of LF08-0299 (Tresperimus) and analogues. Int J Immunopharmacol. 1999 May;21(5):349-58. PubMed PMID: 10408631.10: Annat J, Dutartre P. T cell repertoire expression in murine recipients of bone marrow transplant after LF 08-0299 (Tresperimus) administration. Transpl Immunol. 1998 Dec;6(4):217-24. PubMed PMID: 10342735.1

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