2933-94-0|Toliprolol|1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol|-范德生物科技公司

Toliprolol

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names：
1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol
CAS号：
2933-94-0
MDL Number：
MF(分子式)： C13H21NO2 MW(分子量)： 223.32
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol
英文别名	Toliprolol; Toliprololum; MHIP;
CAS号	2933-94-0
SMILES	OC(COC1=CC=CC(C)=C1)CNC(C)C
Inchi	InChI=1S/C13H21NO2/c1-10(2)14-8-12(15)9-16-13-6-4-5-11(3)7-13/h4-7,10,12,14-15H,8-9H2,1-3H3
InchiKey	NXQMNKUGGYNLBY-UHFFFAOYSA-N
分子式 Formula	C13H21NO2
分子量 Molecular Weight	223.32
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Toliprolol(CAS:2933-94-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Toliprolol is an adrenergic receptor antagonist with some stimulant action; it has been proposed for angina pectoris.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Gane P, Stroesco V, Granici A. [Research on the relation between beta-adrenergic blockade with propranolol of toliprolol and the central effects of nialamide]. Physiologie. 1977 Jan-Mar;14(1):21-5. French. PubMed PMID: 16302.

[2]Vierling W, Gorbahn H, Ammon HP, Estler CJ. [Effect of ethanol and toliprolol on the carbohydrate metabolism of the brain and liver]. Arzneimittelforschung. 1980;30(5):773-6. German. PubMed PMID: 6104970.

[3] Wuppermann D, Zimmermann F, Friedrich L. [Comparative study on the effects of alprenolol, bunitrolol, ethaverine, oxprenolol, papaverine, practolol, pindolol, pronethalol, propranolol, toliprolol and verapamil on cardiac and bronchial beta-receptors (author's transl)]. Arzneimittelforschung. 1978;28(5):794-8. German. PubMed PMID: 35172.

[4] Doze P, Elsinga PH, Maas B, Van Waarde A, Wegman T, Vaalburg W. Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET. Neurochem Int. 2002 Feb;40(2):145-55. PubMed PMID: 11738481.

[5] Gogaladze K, Chankvetadze L, Tsintsadze M, Farkas T, Chankvetadze B. Effect of basic and acidic additives on the separation of some basic drug enantiomers on polysaccharide-based chiral columns with acetonitrile as mobile phase. Chirality. 2015 Mar;27(3):228-34. doi: 10.1002/chir.22417. Epub 2015 Jan 6. PubMed PMID: 25564994.

6: Sada H, Ban T. Frequency-dependent block of nerve conduction by beta-adrenergic blocking agents. Arch Int Pharmacodyn Ther. 1981 Nov;254(1):134-44. PubMed PMID: 6121535.7: White JD, Shaw S. A new catalyst for the asymmetric Henry reaction: synthesis of β-nitroethanols in high enantiomeric excess. Org Lett. 2012 Dec 21;14(24):6270-3. doi: 10.1021/ol3030023. Epub 2012 Nov 30. PubMed PMID: 23194499.8: Bartsch W, Dietmann K, Leinert H, Sponer G. Cardiac action of carazolol and methypranol in comparison with other beta-receptor blockers. Arzneimittelforschung. 1977;27(5):1022-6. PubMed PMID: 18157.9: Breier C, Kain H, Konzett H. The variance of forearm blood flow as an indicator of emotional stress. Eur J Clin Pharmacol. 1983;25(4):535-8. PubMed PMID: 6228433.10: Marmol F, Puig-Parellada P, Forn J. Interactions of lithium with the adrenergic system in electrically-stimulated guinea pig myenteric plexus isolated preparations. Actions of a phosphodiesterase inhibitor. Methods Find Exp Clin Pharmacol. 1992 Oct;14(8):623-8. PubMed PMID: 1283616.1

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