83058-69-9|Tfc 612|Hexanoic acid, 6-((3-hydroxy-2-(3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)thio)-, methyl ester, (1R-(1alpha,2beta(1E,3S*,5R*),3alpha))-|-范德生物科技公司

Tfc 612

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names：
Hexanoic acid, 6-((3-hydroxy-2-(3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)thio)-, methyl ester, (1R-(1alpha,2beta(1E,3S*,5R*),3alpha))-
CAS号：
83058-69-9
MDL Number：
MF(分子式)： C22H38O5S MW(分子量)： 414.601
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Hexanoic acid, 6-((3-hydroxy-2-(3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)thio)-, methyl ester, (1R-(1alpha,2beta(1E,3S,5R),3alpha))-
英文别名	Tfc 612; Tfc-612; Tfc612
CAS号	83058-69-9
Inchi	InChI=1S/C22H38O5S/c1-4-5-9-16(2)14-17(23)11-12-18-19(24)15-20(25)22(18)28-13-8-6-7-10-21(26)27-3/h11-12,16-19,22-24H,4-10,13-15H2,1-3H3/b12-11+/t16-,17?,18+,19-,22-/m1/s1
InchiKey	KMYUINCCFSNYPC-VPTZPLTNSA-N
分子式 Formula	C22H38O5S
分子量 Molecular Weight	414.601
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Tfc 612(CAS:83058-69-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Tfc 612 prevents decrease in motor nerve conduction velocity in streptozocin-diabetic rats and is a derivative of thiaprostaglandin E1.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Yasuda H, Sonobe M, Yamashita M, Terada M, Hatanaka I, Huitian Z, Shigeta Y. Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235. Diabetes. 1989 Jul;38(7):832-8. PubMed PMID: 2525492.

[2]Motoyama Y, Sakata Y, Seki J, Asada T, Namikawa Y, Horiai H, Ono T. The effects of TFC-612, a 7-thia prostaglandin E1 derivative, on platelet function. Thromb Res. 1991 Jul 1;63(1):29-38. PubMed PMID: 1658963.

[3] Motoyama Y, Sakata Y, Seki J, Dohi M, Yoshida K. Effect of TFC-612, a 7-thia prostaglandin E1 derivative, on a peripheral arterial occlusive disease model in rats. Prostaglandins. 1995 Mar;49(3):175-82. PubMed PMID: 7652186.

[4] Suzuki K, Saito N, Sakata Y, Toyota T, Goto Y. A new prostaglandin E1 analogue (TFC-612) improves the reduction in motor nerve conduction velocity in spontaneously diabetic GK (Goto-Kakizaki) rats. Prostaglandins. 1990 Nov;40(5):463-71. PubMed PMID: 2255766.

[5] Yasuda H, Sonobe M, Hatanaka I, Yamashita M, Miyamoto Y, Terada M, Amenomori M, Kikkawa R, Shigeta Y, Motoyama Y, et al. A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats. Biochem Biophys Res Commun. 1988 Jan 15;150(1):225-30. PubMed PMID: 3276309.

6: Motoyama Y, Sakata Y, Seki J, Asada T, Namikawa Y, Horiai H, Ono T. The effects of TFC-612, a 7-THIA prostaglandin E1 derivative, on platelet function. Thromb Res. 1991 Jun 1;62(5):471-80. PubMed PMID: 1654599.7: Motoyama Y, Sakata Y, Seki J, Sato M, Namikawa Y, Horiai H, Ono T. TFC-612, a prostaglandin E1 derivative, enhances fibrinolytic activity in rats. Thromb Res. 1992 Jan 1;65(1):55-63. PubMed PMID: 1604443.8: Motoyama Y, Seki J, Katoh Y, Nishio M, Yoshida K. Effect of TFC-612, a 7-thia prostaglandin E1 derivative, on intimal thickening after endothelial injury with balloon catheter in rats. Atherosclerosis. 1994 Aug;108(2):159-65. PubMed PMID: 7980715.9: Tanaka H, Minoshima T, Endo N. The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells. Br J Pharmacol. 1995 Oct;116(4):2298-302. PubMed PMID: 8564263; PubMed Central PMCID: PMC1908987.10: Nagamatsu T, Kojima J, Ito M, Kondo N, Suzuki Y. Antinephritic effects of PGE1 and thiaprostaglandin E1, TEI-5178 and TEI-6122, on crescentic-type anti-GBM nephritis in rats. Jpn J Pharmacol. 1989 Dec;51(4):521-30. PubMed PMID: 2615044.

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