146939-64-2|TF-505|(S)-4-(1-(4-(1-(4-isobutylphenyl)butoxy)benzoyl)indolizin-3-yl)butanoic acid|-范德生物科技公司

TF-505

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names：
(S)-4-(1-(4-(1-(4-isobutylphenyl)butoxy)benzoyl)indolizin-3-yl)butanoic acid
CAS号：
146939-64-2
MDL Number：
MF(分子式)： C33H37NO4 MW(分子量)： 511.662
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-4-(1-(4-(1-(4-isobutylphenyl)butoxy)benzoyl)indolizin-3-yl)butanoic acid
英文别名	TF-505; TF 505; FK-687; FR-146687; TF505; FK687; FR146687.
CAS号	146939-64-2
Inchi
InchiKey
分子式 Formula	C33H37NO4
分子量 Molecular Weight	511.662
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	TF-505(CAS:146939-64-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	TF-505, also known as FK-687; FR-146687, is a steroid 5α-reductase inhibitor potentially for the treatment of benign prostatic hyperplasia.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Yao Z, Krzyzanski W, Jusko WJ. Assessment of basic indirect pharmacodynamic response models with physiological limits. J Pharmacokinet Pharmacodyn. 2006 Apr;33(2):167-93. PubMed PMID: 16547797.

[2]Matsumoto Y, Fujita T, Ishida Y, Shimizu M, Kakuo H, Yamashita K, Majima M, Kumagai Y. Population pharmacokinetic-pharmacodynamic modeling of TF-505 using extension of indirect response model by incorporating a circadian rhythm in healthy volunteers. Biol Pharm Bull. 2005 Aug;28(8):1455-61. PubMed PMID: 16079492.

[3] Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. March 2003. Methods Find Exp Clin Pharmacol. 2003 Mar;25(2):145-68. PubMed PMID: 12731460.

[4] Fujita T, Matsumoto Y, Kimura T, Yokota S, Sawada M, Majima M, Ohtani Y, Kumagai Y. Pharmacokinetics and pharmacodynamics of TF-505, a novel nonsteroidal 5alpha-reductase inhibitor, in normal subjects treated with single or multiple doses. Br J Clin Pharmacol. 2002 Sep;54(3):283-94. PubMed PMID: 12236849; PubMed Central PMCID: PMC1874425.

[5] Nakayama O, Hirosumi J, Chida N, Takahashi S, Sawada K, Kojo H, Notsu Y. FR146687, a novel steroid 5 alpha-reductase inhibitor: in vitro and in vivo effects on prostates. Prostate. 1997 Jun 1;31(4):241-9. PubMed PMID: 9180934.

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