936475-62-6|TBE-31|(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile|-范德生物科技公司

TBE-31

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names：
(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile
CAS号：
936475-62-6
MDL Number：
MF(分子式)： C21H18N2O2 MW(分子量)： 330.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile
英文别名	TBE-31; TBE 31; TBE31;
CAS号	936475-62-6
SMILES	N#CC(C(C=C1[C@@]2(C)C=C3C#N)=O)=C[C@]1(C#C)CC[C@H]2C(C)(C)C3=O
Inchi	InChI=1S/C21H18N2O2/c1-5-21-7-6-16-19(2,3)18(25)14(12-23)9-20(16,4)17(21)8-15(24)13(10-21)11-22/h1,8-10,16H,6-7H2,2-4H3/t16-,20-,21-/m0/s1
InchiKey	ISZIRXMFUSQQOS-NDXORKPFSA-N
分子式 Formula	C21H18N2O2
分子量 Molecular Weight	330.38
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	TBE-31(CAS:936475-62-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	TBE-31 is a highly potent activator of Nrf2. It also acts as a potent phase 2 cytoprotective pathway inducer and liver carcinogenesis blocker.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K. Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression. Eur J Pharmacol. 2016 Dec 15;79

3:21-27. doi: 10.1016/j.ejphar.2016.10.037. Epub 2016 Nov 1. PubMed PMID: 27815170.

[3]Chan E, Saito A, Honda T, Di Guglielmo GM. The acetylenic tricyclic bis(cyano enone), TBE-31, targets microtubule dynamics and cell polarity in migrating cells. Biochim Biophys Acta. 2016 Apr;1863(4):638-49. doi: 10.1016/j.bbamcr.2016.01.008. Epub 2016 Jan 13. PubMed PMID: 26775215.

[4]Kostov RV, Knatko EV, McLaughlin LA, Henderson CJ, Zheng S, Huang JT, Honda T, Dinkova-Kostova AT. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action. Biochem Biophys Res Commun. 2015 Sep 25;465(3):402-7. doi: 10.1016/j.bbrc.2015.08.016. Epub 2015 Aug 8. PubMed PMID: 26265043; PubMed Central PMCID: PMC4567061.

[5] Abeti R, Uzun E, Renganathan I, Honda T, Pook MA, Giunti P. Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia. Pharmacol Res. 2015 Sep;99:344-50. doi: 10.1016/j.phrs.2015.05.015. Epub 2015 Jul 2. PubMed PMID: 26141703.

5: Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT. Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans. Cancer Prev Res (Phila). 2015 Jun;8(6):475-86. doi: 10.1158/1940-6207.CAPR-14-0362. Epub 2015 Mar 24. PubMed PMID: 25804610; PubMed Central PMCID: PMC4454593.

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