143162-65-6|Spr 210|2H-1,4-Benzothiazine-2-aceticacid, 3,4-dihydro-3-oxo-4-[(4,5,7-trifluoro-2-benzothiazolyl)methyl]-|-范德生物科技公司

Spr 210

NMR下载 COA and HPLC MSDS下载
names：
2H-1,4-Benzothiazine-2-aceticacid, 3,4-dihydro-3-oxo-4-[(4,5,7-trifluoro-2-benzothiazolyl)methyl]-
CAS号：
143162-65-6
MDL Number：
MF(分子式)： C18H11F3N2O3S2 MW(分子量)： 424.4122
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	2H-1,4-Benzothiazine-2-aceticacid, 3,4-dihydro-3-oxo-4-[(4,5,7-trifluoro-2-benzothiazolyl)methyl]-
英文别名	Spr 210; SG 210; Spr210; SG210; Spr-210; SG-210
CAS号	143162-65-6
Inchi	InChI=1S/C18H11F3N2O3S2/c19-8-5-9(20)17-16(15(8)21)22-13(28-17)7-23-10-3-1-2-4-11(10)27-12(18(23)26)6-14(24)25/h1-5,12H,6-7H2,(H,24,25)
InchiKey	BUYWFAJWTSIACV-UHFFFAOYSA-N
分子式 Formula	C18H11F3N2O3S2
分子量 Molecular Weight	424.4122
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Spr 210(CAS:143162-65-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Spr 210 is an aldose reductase (AR) inhibitor with potential uses as a therapeutic agent for preventing and improving some diabetic complications.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Matsui T, Nakamura Y, Ishikawa H, Matsuura A, Kobayashi F. Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats. Jpn J Pharmacol. 1994 Feb;64(2):115-24. PubMed PMID: 8028228.

[2]Aotsuka T, Hosono H, Kurihara T, Nakamura Y, Matsui T, Kobayashi F. Novel and potent aldose reductase inhibitors: 4-benzyl- and 4-(benzothiazol-2-ylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-2-ac etic acid derivatives. Chem Pharm Bull (Tokyo). 1994 Jun;42(6):1264-71. PubMed PMID: 8069975.

[3] Akira T, Naka H. [SG-210]. Nihon Rinsho. 1997 Nov;55 Suppl:216-20. Review. Japanese. PubMed PMID: 9434470.

[4] Horie S, Nagai H, Yuuki T, Narita Y, Tsuda Y, Nakajima T, Nakamura N. Effect of SG-210, a novel aldose reductase inhibitor, on impaired polyol pathway in rats received diabetic manipulations. J Diabetes Complications. 1998 May-Jun;12(3):163-9. PubMed PMID: 9618072.

[5] Weikert LF, Lopez JP, Abdolrasulnia R, Chroneos ZC, Shepherd VL. Surfactant protein A enhances mycobacterial killing by rat macrophages through a nitric oxide-dependent pathway. Am J Physiol Lung Cell Mol Physiol. 2000 Aug;279(2):L216-23. PubMed PMID: 10926544.

6: Ino-Ue M, Zhang L, Naka H, Kuriyama H, Yamamoto M. Polyol metabolism of retrograde axonal transport in diabetic rat large optic nerve fiber. Invest Ophthalmol Vis Sci. 2000 Dec;41(13):4055-8. PubMed PMID: 11095594.7: Azuma M, Inoue E, Oka T, Shearer TR. Proteolysis by calpain is an underlying mechanism for formation of sugar cataract in rat lens. Curr Eye Res. 1995 Jan;14(1):27-34. PubMed PMID: 7720403.

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