35882-85-0|SGE-201|(3S,8S,9S,10R,13R,14S,17R)-17-((R)-5-hydroxy-5-methylhexan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol|-范德生物科技公司

SGE-201

NMR下载 COA and HPLC MSDS下载
names：
(3S,8S,9S,10R,13R,14S,17R)-17-((R)-5-hydroxy-5-methylhexan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS号：
35882-85-0
MDL Number：
MF(分子式)： C26H44O2 MW(分子量)： 388.636
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(3S,8S,9S,10R,13R,14S,17R)-17-((R)-5-hydroxy-5-methylhexan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
英文别名	SGE-201; SGE 201; SGE201; delta5,6-3-oxynorcholenyl)dimethylcarbinol
CAS号	35882-85-0
SMILES	CC(C)(O)CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Inchi	InChI=1S/C26H44O2/c1-17(10-13-24(2,3)28)21-8-9-22-20-7-6-18-16-19(27)11-14-25(18,4)23(20)12-15-26(21,22)5/h6,17,19-23,27-28H,7-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,25+,26-/m1/s1
InchiKey	USOOWRCOYYNZPU-LXVLQKCJSA-N
分子式 Formula	C26H44O2
分子量 Molecular Weight	388.636
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SGE-201(CAS:35882-85-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SGE-201 is a potent allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 is an analogue of an endogenous oxysterol. bSGE-201 increased the actions of memantine and ketamine on phasic excitatory post-synaptic currents, but neither revealed underlying pharmacodynamic differences. SGE-201 accelerated the re-equilibration of blockers during voltage jumps. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild excitotoxic insult.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF,Mennerick S. Interaction between positive allosteric modulators and trappingblockers of the NMDA receptor channel. Br J Pharmacol. 2015 Mar;172(5):1333-47.doi: 10.1111/bph.13007. Epub 2015 Jan 13. PubMed PMID: 25377730; PubMed CentralPMCID: PMC4337705.

[2]Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, CrawfordDC, Linsenbardt AJ, Shu HJ, Izumi Y, Mennerick SJ, Zorumski CF. The major braincholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulatorof N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300. doi:10.1523/JNEUROSCI.2619-13.2013. PubMed PMID: 24174662; PubMed Central PMCID:PMC3812502.

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