83440-03-3|SG-209|N-[2-(Acetoxy)ethyl]-3-pyridinecarboxamide|-范德生物科技公司

SG-209

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names：
N-[2-(Acetoxy)ethyl]-3-pyridinecarboxamide
CAS号：
83440-03-3
MDL Number：
MF(分子式)： C10H12N2O3 MW(分子量)： 208.21
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	N-[2-(Acetoxy)ethyl]-3-pyridinecarboxamide
英文别名	SG-209; SG 209; SG209;
CAS号	83440-03-3
SMILES	O=C(C1=CC=CN=C1)NCCOC(C)=O
Inchi	InChI=1S/C10H12N2O3/c1-8(13)15-6-5-12-10(14)9-3-2-4-11-7-9/h2-4,7H,5-6H2,1H3,(H,12,14)
InchiKey	JQICNNKLTFYSLS-UHFFFAOYSA-N
分子式 Formula	C10H12N2O3
分子量 Molecular Weight	208.21
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SG-209(CAS:83440-03-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SG-209 is a potassium channel opener.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Umaru B, Pyriochou A, Kotsikoris V, Papapetropoulos A, Topouzis S. ATP-sensitive potassium channel activation induces angiogenesis in vitro and in vivo. J Pharmacol Exp Ther. 2015 Jul;354(1):79-87. doi: 10.1124/jpet.114.222000. Epub 2015 May 14. PubMed PMID: 25977483.

[2]Parimala K, Peedicayil J, Peedicayil A, Nelson N, Ernest K. The effect of a nicorandil congener on isolated human myometrium. Eur J Obstet Gynecol Reprod Biol. 2006 Jun 1;126(2):176-9. Epub 2005 Oct 10. PubMed PMID: 16216408.

[3] Wei XM, Heywood GJ, Di Girolamo N, Thomas PS. Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes. Int Immunopharmacol. 2003 Nov;3(12):1581-8. PubMed PMID: 14555283.

[4] Heywood GJ, Thomas PS. Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells. Inflamm Res. 2002 Apr;51(4):176-81. PubMed PMID: 12058954.

[5] Satoh K, Orito K, Yoneyama F, Taira N. A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart. Cardiovasc Drugs Ther. 1994 Apr;8(2):227-34. PubMed PMID: 7918135.

6: Abe S, Nishimura J, Nakamura M, Kanaide H. Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery. J Pharmacol Exp Ther. 1994 Feb;268(2):762-71. PubMed PMID: 8113988.7: Satoh K, Yamada H, Yoneyama F, Taira N. The group at C2 of N-ethylnicotinamide determines the vasodilator potencies and mechanisms of action of nicorandil and its congeners in canine coronary arteries. Naunyn Schmiedebergs Arch Pharmacol. 1991 Nov;344(5):589-95. PubMed PMID: 1839805.8: Ishibashi T, Hamaguchi M, Imai S. 2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: structure activity relationship among nicorandil derivatives. Naunyn Schmiedebergs Arch Pharmacol. 1991 Aug;344(2):235-9. PubMed PMID: 1658666.9: Yonekura H, Iwatsuki K, Horiuchi A, Chiba S. Effects of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil; SG-75) and its derivatives on pancreatic exocrine secretion in the dog. Pancreas. 1990;5(1):75-81. PubMed PMID: 1688393.10: Maruyama M, Satoh K, Taira N. Effects of nicorandil and its congeners on musculature and vasculature of the dog trachea in situ. Arch Int Pharmacodyn Ther. 1982 Aug;258(2):260-6. PubMed PMID: 6215905.

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