79775-19-2|Septide|(S)-N-((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-phenylalanyl-L-phenylalanyl)pyrrolidine-2-carboxamide|-范德生物科技公司

Septide

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names：
(S)-N-((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-phenylalanyl-L-phenylalanyl)pyrrolidine-2-carboxamide
CAS号：
79775-19-2
MDL Number：
MF(分子式)： C39H53N7O7S MW(分子量)： 763.95
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-N-((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-phenylalanyl-L-phenylalanyl)pyrrolidine-2-carboxamide
英文别名	Septide; 6-Glp-9-pro-substance P (6-11); Substance P (6-11), pyroglutamyl(6)-proline(9)-;
CAS号	79775-19-2
Inchi	InChI=1S/C39H53N7O7S/c1-24(2)21-29(36(50)42-27(34(40)48)18-20-54-3)44-38(52)32-15-10-19-46(32)39(53)31(23-26-13-8-5-9-14-26)45-37(51)30(22-25-11-6-4-7-12-25)43-35(49)28-16-17-33(47)41-28/h4-9,11-14,24,27-32H,10,15-23H2,1-3H3,(H2,40,48)(H,41,47)(H,42,50)(H,43,49)(H,44,52)(H,45,51)/t27-,28-,29-,30-,31-,32-/m0/s1
InchiKey	UUZURPUIMYJOIL-JNRWAQIZSA-N
分子式 Formula	C39H53N7O7S
分子量 Molecular Weight	763.95
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Septide(CAS:79775-19-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Septide is an agonist for the NK1 receptor acting at a site distinct from substance P.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Torrens Y, Beaujouan JC, Saffroy M, Glowinski J. Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder. Peptides. 1995;16(4):587-94. PubMed PMID: 7479288.

[2]Ahluwalia A, Giuliani S, Maggi CA. Demonstration of a 'septide-sensitive' inflammatory response in rat skin. Br J Pharmacol. 1995 Oct;116(4):2170-4. PubMed PMID: 8564245; PubMed Central PMCID: PMC1908977.

[3] Huleux C, Berthier A, Rossignol B, Dreux C. A "septide-sensitive" receptor is not involved in tachykinin-mediated secretory and inositol phosphate responses in rat parotid gland: are several transduction pathways involved after the stimulation of the NK1 receptor? J Neurochem. 1998 Feb;70(2):858-64. PubMed PMID: 9453583.

[4] Ricciardolo FL, Trevisani M, Geppetti P, Nadel JA, Amadesi S, Bertrand C. Role of nitric oxide and septide-insensitive NK(1) receptors in bronchoconstriction induced by aerosolised neurokinin A in guinea-pigs. Br J Pharmacol. 2000 Mar;129(5):915-20. PubMed PMID: 10696090; PubMed Central PMCID: PMC1571918.

[5] Hastrup H, Schwartz TW. Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis. FEBS Lett. 1996 Dec 16;399(3):264-6. PubMed PMID: 8985159.

6: Menéndez L, Hidalgo A, Baamonde A. Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior. Eur J Pharmacol. 1997 Sep 17;335(1):9-14. PubMed PMID: 9371540.7: Figini M, Emanueli C, Bertrand C, Javdan P, Geppetti P. Evidence that tachykinins relax the guinea-pig trachea via nitric oxide release and by stimulation of a septide-insensitive NK1 receptor. Br J Pharmacol. 1996 Mar;117(6):1270-6. PubMed PMID: 8882625; PubMed Central PMCID: PMC1909790.8: Gauchy C, Desban M, Glowinski J, Kemel ML. Distinct regulations by septide and the neurokinin-1 tachykinin receptor agonist [pro9]substance P of the N-methyl-D-aspartate-evoked release of dopamine in striosome- and matrix-enriched areas of the rat striatum. Neuroscience. 1996 Aug;73(4):929-39. PubMed PMID: 8809812.9: Beaujouan JC, Saffroy M, Torrens Y, Sagan S, Glowinski J. Pharmacological characterization of tachykinin septide-sensitive binding sites in the rat submaxillary gland. Peptides. 1999 Nov;20(11):1347-52. PubMed PMID: 10612450.10: Pradier L, Ménager J, Le Guern J, Bock MD, Heuillet E, Fardin V, Garret C, Doble A, Mayaux JF. Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. Mol Pharmacol. 1994 Feb;45(2):287-93. PubMed PMID: 7509440.1

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