287383-59-9|Scriptaid|Scriptaid, HDAC inhibitor|MFCD00386477-范德生物科技公司

Scriptaid

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names：
Scriptaid, HDAC inhibitor
CAS号：
287383-59-9
MDL Number： MFCD00386477
MF(分子式)： C18H18N2O4 MW(分子量)： 326
EINECS: Reaxys Number:
Pubchem ID:5186 Brand:BIOFOUNT

Scriptaid 是一种组蛋白去乙酰化酶抑制剂，在基于细胞的检测中，最佳浓度为 6-8 μM，毒性低于曲古抑菌素 A，适用于多种生物系统。Scriptaid 可诱导结肠癌细胞的细胞周期停滞在培养和体外和体内抑制肿瘤生长。Scriptaid 还有助于克隆由体细胞核移植产生的近交小鼠品系。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
LSH65884-50mg	50mg	98%	¥ 4480.00	¥ 4480.00		1-3days	- +	¥ 0.00
LSH65884-10mg	10mg	98%	¥ 1180.00	¥ 1180.00		1-3days	- +	¥ 0.00

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询价

中文别名	Scriptaid(287383-59-9);组蛋白去乙酰化酶 (HDAC) 抑制剂;HDAC抑制剂;组蛋白去乙酰化酶抑制剂;Scriptide;GCK1026
英文别名	Scriptaid, HDAC inhibitor(287383-59-9);potent histone deacetylase (HDAC) inhibitor
CAS号	287383-59-9
SMILES	C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO
Inchi	InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InchiKey	JTDYUFSDZATMKU-UHFFFAOYSA-N
分子式 Formula	C18H18N2O4
分子量 Molecular Weight	326
闪点 FP	Not available
熔点 Melting point	Not available
沸点 Boiling point	Not available
Polarizability极化度	Not available
密度 Density	Not available
蒸汽压 Vapor Pressure	Not available
溶解度Solubility
性状	Solid,Powder
储藏条件 Storage conditions	storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

体外研究

Scriptaid (6 μM) results in a >100-fold increase in histone acetylation in PANC-1 cell. Scriptaid (8 μM) is not lethal to PANC-1 cell and has limited effects (80% survival) on MDAMB-468. Scriptaid increases the transcription of pCMVb, p6SBE-luc and p6MBE-luc independent of a positive inducer of transcription. Scriptaid is capable of inducing high expression of p6MBE-luc, pCMVb, and pUB6/V5-LacZ, driven by viral (SV40 and CMV) or human (ubiquitin c, UB6) promoters, which do not depend on the specificity of the enhancer (SBE versus MBE), the type of promoter (viral versus cellular), the product of the reporter gene (luciferase versus b-gal), nor on the integration status of the reporter construct. Scriptaid induces high rates of somatic cell nuclear transfer (SCNT) oocytes development to the blastocyst stage and allowed full-term development (3.4, 4.2, 7.6, 6.8, and 4.1%) with all concentrations (50, 100, 250, 500, and 2000 nM respectively). Scriptaid improves the full-term development of cloned B6D2F1embryos in a dose-dependent manner with the maximum effect at 250 nM. Scriptaid enables the clone of all the important inbred mouse strains, such as C57BL/6, C3H/He, DBA/2, and 129/Sv. Scriptaid treatment enhances newly synthesized mRNA levels in cloned embryos. 250 nM Scriptaid treated for up to 48 h, does not inhibit the development of ICSI-fertilized embryos. Scriptaid inhibits T. gondii tachyzoite proliferation with IC50 of 39 nM. Scriptaid (0.225 μM) completely protects the HS68 monolayers from T. gondii tachyzoite.Scriptaid inhibits growth of ER negative cell lines, MDA-MB-231, MDA-MB-435 and Hs578t with IC50 of 0.5-1.0 μg/mL after 48 h treatment. 1 μg/ml Scriptaid treated for 48 h induces an accumulation of both acetylated H3 and acetylated H4 histone tail proteins, and a maximal of 20,000-fold increase of ER mRNA transcript. Scriptaid inhibits the proliferation and viability of the Ishikawa endometrial cancer cell line, and the SK-OV-3 ovarian cancer cell line with IC50 of 9 μM and 55 μM, respectively, while the normal human endometrial epithelial cells shows little sensitivity. Endometrial cancer cells and ovarian cancer cells cultured for 2 days in the presence of Scriptaid shows an accumulation in the G0/G1 phase (5 μM of Scriptaid) and G2/M phase (10 μM of Scriptaid) of the cell cycle, with a concomitant decrease in the proportion of those in the S phase. 10 μM of Scriptaid induces a 56.1% of apoptotic Ishikawa cells with loss of mitochondrial membrane potential, and decreased levels of cyclin A and bcl-2 levels by 50% and 20%, respectively.

体内研究

Scriptaid elicits a dose-dependent decrease in lesion size (a maximal decrease of 45%) at 1.5 to 5.5 mg/kg and a concomitant attenuation in motor and cognitive deficits when delivered 30 minutes postinjury in a model of mode rate TBI. Comparable protection is achieved even when treatment is delayed to 12 h postinjury. The protection of motor and cognitive functions is long lasting, as similar improvements are detected 35 days postinjury. Scriptaid induces an increase in surviving neurons (42%), as well as the number/length of their processes within the CA3 region of the hippocampus and the pericontusional cortex. Scriptaid treatment prevents the decrease in phospho-AKT (p-AKT) and phosphorylated phosphatase and tensin homolog deleted on chromosome 10 ( p-PTEN) induced by TBI in cortical and CA3 hippocampal neurons. Scriptaid treatment (3.5 mg/kg) clearly inhibits tumor growth in a human breast cancer xenograft MDA-MB-231 model, reducing tumor volume by 75%.

产品说明	Scriptaid, 一种组蛋白去乙酰化酶 (HDAC) 抑制剂, 可用于癌症研究仅用于科学研究实验使用，不得用于其他用途
Introduction	Scriptaid, a potent histone deacetylase (HDAC) inhibitor, used in cancer research Only used for scientific research experiments, not for other purposes
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

1.Reduced Histone Deacetylase 7 Activity Restores Function to Misfolded CFTR in Cystic Fibrosis.（PMID 19966789)

2.Chemical Phylogenetics of Histone Deacetylases.(Nature Chemical Biology,PMID 20139990)

3. Lee, E.J., Lee, B.B., Kim, S.J., et al. Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. Int. J. Oncol. 33, 767-776 (2008).

4. Van Thuan, N., Bui, H.T., Kim, J.H., et al. The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice.

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