11056-18-1|Scopafungin|3-oxo-3-(((10E,12Z,20E)-5,7,9,19,23,25,27,31,33,34,35-undecahydroxy-8,14,18,22,26,30-hexamethyl-15-((E)-4-methyl-12-(3-methylguanidino)dodec-8-en-2-yl)-17-oxo-16,37-dioxabicyclo[31.3.1]heptatriaconta-10,12,20-trien-3-yl)oxy)propanoic acid|-范德生物科技公司

Scopafungin

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names：
3-oxo-3-(((10E,12Z,20E)-5,7,9,19,23,25,27,31,33,34,35-undecahydroxy-8,14,18,22,26,30-hexamethyl-15-((E)-4-methyl-12-(3-methylguanidino)dodec-8-en-2-yl)-17-oxo-16,37-dioxabicyclo[31.3.1]heptatriaconta-10,12,20-trien-3-yl)oxy)propanoic acid
CAS号：
11056-18-1
MDL Number：
MF(分子式)： C59H103N3O18 MW(分子量)： 1142.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3-oxo-3-(((10E,12Z,20E)-5,7,9,19,23,25,27,31,33,34,35-undecahydroxy-8,14,18,22,26,30-hexamethyl-15-((E)-4-methyl-12-(3-methylguanidino)dodec-8-en-2-yl)-17-oxo-16,37-dioxabicyclo[31.3.1]heptatriaconta-10,12,20-trien-3-yl)oxy)propanoic acid
英文别名	Scopafungin; N-29479; N 29479; N29479; Nificin; U 29479; U-29479; U29479;
CAS号	11056-18-1
Inchi	InChI=1S/C59H103N3O18/c1-34(18-14-12-10-11-13-17-25-62-58(60)61-9)26-38(5)55-37(4)19-15-16-20-45(64)39(6)49(68)28-42(63)27-43(78-54(74)32-53(72)73)29-44-30-51(70)56(75)59(77,80-44)33-52(71)36(3)22-23-46(65)40(7)50(69)31-48(67)35(2)21-24-47(66)41(8)57(76)79-55/h10-11,15-16,19-21,24,34-52,55-56,63-71,75,77H,12-14,17-18,22-23,25-33H2,1-9H3,(H,72,73)(H3,60,61,62)/b11-10+,19-15-,20-16+,24-21+
InchiKey	VAYOSPAPALLOIO-GTGIXXMMSA-N
分子式 Formula	C59H103N3O18
分子量 Molecular Weight	1142.47
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Scopafungin(CAS:11056-18-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Scopafungin is a crystalline, nonpolyenic antimicrobial agent that is used as an antifungal.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Takesako K, Nakamura T, Obayashi A, Iwasaki S, Namikoshi M, Okuda S, Beppu T. Demalonyl derivatives of azalomycin F4 and scopafungin. J Antibiot (Tokyo). 1986 May;39(5):713-6. PubMed PMID: 3733520.

[2]Johnson LE, Dietz A. Scopafungin, a crystalline antibiotic produced by Streptomyces hygroscopicus var. enhygrus var. nova. Appl Microbiol. 1971 Sep;22(3):303-8. PubMed PMID: 4940870; PubMed Central PMCID: PMC376304.

[3] Reusser F. Scopafungin, an inhibitor of oxidative phosphorylation in mitochondria. Biochem Pharmacol. 1972 Apr 1;21(7):1031-8. PubMed PMID: 4339110.

[4] Bergy ME, Hoeksema H. Scopafungin, a crystalline endomycin component. J Antibiot (Tokyo). 1972 Jan;25(1):39-43. PubMed PMID: 5010644.

[5] Mogi T, Matsushita K, Murase Y, Kawahara K, Miyoshi H, Ui H, Shiomi K, Omura S, Kita K. Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II). FEMS Microbiol Lett. 2009 Feb;291(2):157-61. doi: 10.1111/j.1574-6968.2008.01451.x. Epub 2008 Dec 5. PubMed PMID: 19076229.

6: Dolak LA, Reusser F, Baczynskyj L, Mizsak SA, Hannon BR, Castle TM. Desertomycin: purification and physical-chemical properties. J Antibiot (Tokyo). 1983 Jan;36(1):13-9. PubMed PMID: 6678910.7: Kumazawa S, Asami Y, Awane K, Ohtani H, Fukuchi C, Mikawa T, Hayase T. Structural studies of new macrolide antibiotics, shurimycins A and B. J Antibiot (Tokyo). 1994 Jun;47(6):688-96. PubMed PMID: 8040074.8: Stefanelli S, Corti E, Montanini N, Denaro M, Sarubbi E. Inhibitors of type-I interleukin-1 receptor from microbial metabolites. J Antibiot (Tokyo). 1997 Jun;50(6):484-9. PubMed PMID: 9268004.9: Kuimova TF, Kazakov GA, Inshakova TA. [Spontaneous crystallization of antibiotic substance during submerged fermentation of Actinomyces hygroscopicus]. Mikrobiologiia. 1976 JUL-AUG;45(4):746-9. Russian. PubMed PMID: 979694.

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