420785-70-2|SB 649915|6-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]-4H-1,4-benzoxazin-3-one|-范德生物科技公司

SB 649915

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names：
6-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]-4H-1,4-benzoxazin-3-one
CAS号：
420785-70-2
MDL Number：
MF(分子式)： C26H29N3O3 MW(分子量)： 431.54
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	6-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]-4H-1,4-benzoxazin-3-one
英文别名	SB 649915; SB-649915; SB649915.
CAS号	420785-70-2
Inchi	InChI=1S/C26H29N3O3/c1-18-5-7-21-22(27-18)3-2-4-24(21)31-14-13-29-11-9-19(10-12-29)15-20-6-8-25-23(16-20)28-26(30)17-32-25/h2-8,16,19H,9-15,17H2,1H3,(H,28,30)
InchiKey	PJSUYRBCBFPCQW-UHFFFAOYSA-N
分子式 Formula	C26H29N3O3
分子量 Molecular Weight	431.54
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SB 649915(CAS:420785-70-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SB 649915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist which is being investigated for its antidepressant effects. Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Watson JM, Dawson LA. Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-64991

5: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy. CNS Drug Rev. 2007 Summer;13(2):206-23. Review. PubMed PMID: 17627673.

[3]Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS. SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test. Neuropsychopharmacology. 2007 Oct;32(10):2163-72. Epub 2007 Mar 14. PubMed PMID: 17356576.

[4]Hughes ZA, Starr KR, Scott CM, Newson MJ, Sharp T, Watson JM, Hagan JJ, Dawson LA. Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B. Psychopharmacology (Berl). 2007 May;192(1):121-33. Epub 2007 Jan 30. PubMed PMID: 17265079.

[5] Scott C, Soffin EM, Hill M, Atkinson PJ, Langmead CJ, Wren PB, Faedo S, Gordon LJ, Price GW, Bromidge S, Johnson CN, Hagan JJ, Watson J. SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue. Eur J Pharmacol. 2006 Apr 24;536(1-2):54-61. Epub 2006 Feb 28. PubMed PMID: 16571351.

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