75420-34-7|Saxitoxinol|((3aS,4R,10R)-2,6-diamino-10-hydroxy-3a,4,9,10-tetrahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl)methyl carbamate|-范德生物科技公司

Saxitoxinol

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names：
((3aS,4R,10R)-2,6-diamino-10-hydroxy-3a,4,9,10-tetrahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl)methyl carbamate
CAS号：
75420-34-7
MDL Number：
MF(分子式)： C10H17N7O3 MW(分子量)： 283.29
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	((3aS,4R,10R)-2,6-diamino-10-hydroxy-3a,4,9,10-tetrahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl)methyl carbamate
英文别名	Saxitoxinol; Dihydrosaxitoxin; STXOL;
CAS号	75420-34-7
Inchi	InChI=1S/C10H17N7O3/c11-7-15-6-4(3-20-9(13)19)14-8(12)17-2-1-5(18)10(6,17)16-7/h4-6,18H,1-3H2,(H2,12,14)(H2,13,19)(H3,11,15,16)/t4-,5+,6-,10?/m0/s1
InchiKey	NILHUXIFTLLDPJ-TXDDJGQJSA-N
分子式 Formula	C10H17N7O3
分子量 Molecular Weight	283.29
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Saxitoxinol(CAS:75420-34-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Saxitoxinol is an analog of saxitoxin, a known voltage-gated sodium channel blocker.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kao CY, Kao PN, James-Kracke MR, Koehn FE, Wichmann CF, Schnoes HK. Actions of epimers of 12-(OH)-reduced saxitoxin and of 11-(OSO3)-saxitoxin on squid axon. Toxicon. 1985;23(4):647-55. PubMed PMID: 2414863.

[2]Pearson AD, Williams RM. Synthetic studies towards Zetekitoxin AB: preparation of 4,5-epi-11-hydroxy-saxitoxinol. Tetrahedron. 2014 Oct 28;70(43):7942-7949. PubMed PMID: 25313264; PubMed Central PMCID: PMC4192658.

[3] Ueno S, Nakazaki A, Nishikawa T. A Synthetic Strategy for Saxitoxin Skeleton by a Cascade Bromocyclization: Total Synthesis of (+)-Decarbamoyl-α-saxitoxinol. Org Lett. 2016 Dec 16;18(24):6368-6371. Epub 2016 Dec 5. PubMed PMID: 27978691.

[4] Naseem SM. Toxicokinetics of [3H]saxitoxinol in peripheral and central nervous system of rats. Toxicol Appl Pharmacol. 1996 Nov;141(1):49-58. PubMed PMID: 8917675.

[5] Sawayama Y, Nishikawa T. A synthetic route to the saxitoxin skeleton: synthesis of decarbamoyl α-saxitoxinol, an analogue of saxitoxin produced by the cyanobacterium Lyngbya wollei. Angew Chem Int Ed Engl. 2011 Jul 25;50(31):7176-8. doi: 10.1002/anie.201102494. Epub 2011 Jun 17. PubMed PMID: 21688378.

6: Hines HB, Naseem SM, Wannemacher RW Jr. [3H]-saxitoxinol metabolism and elimination in the rat. Toxicon. 1993 Jul;31(7):905-8. PubMed PMID: 8212035.7: Naseem SM, Creasia DA. Comparative binding and toxicity of saxitoxin and saxitoxinol in mice and in cultured cells. Biochem Mol Biol Int. 1997 Feb;41(2):377-88. PubMed PMID: 9063578.8: Akimoto T, Masuda A, Yotsu-Yamashita M, Hirokawa T, Nagasawa K. Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels. Org Biomol Chem. 2013 Oct 14;11(38):6642-9. doi: 10.1039/c3ob41398e. Epub 2013 Aug 30. PubMed PMID: 23989458.9: Stafford RG, Hines HB. Urinary elimination of saxitoxin after intravenous injection. Toxicon. 1995 Nov;33(11):1501-10. PubMed PMID: 8744989.

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