5092-09-1|Saikogenin A|(3S,4R,4aR,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol|-范德生物科技公司

Saikogenin A

NMR下载 COA and HPLC MSDS下载
names：
(3S,4R,4aR,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol
CAS号：
5092-09-1
MDL Number：
MF(分子式)： C30H48O4 MW(分子量)： 472.71
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(3S,4R,4aR,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol
英文别名	Saikogenin A; Saikogenin D;
CAS号	5092-09-1
SMILES	C[C@@]1(CO)[C@@H](O)CC[C@]2(C)[C@@]3([H])C=CC4=C5CC(C)(C)CC[C@@](CO)5[C@@H](O)C[C@](C)4[C@@](C)3CC[C@@]12[H]
Inchi	InChI=1S/C30H48O4/c1-25(2)13-14-30(18-32)20(15-25)19-7-8-22-26(3)11-10-23(33)27(4,17-31)21(26)9-12-28(22,5)29(19,6)16-24(30)34/h7-8,21-24,31-34H,9-18H2,1-6H3/t21-,22-,23+,24+,26+,27+,28-,29-,30-/m1/s1
InchiKey	QGNVMEXLLPGQEV-HSFRRAFJSA-N
分子式 Formula	C30H48O4
分子量 Molecular Weight	472.71
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Saikogenin A(CAS:5092-09-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Saikogenin A is an anti-inflammatory drug that is present in the crude extract of a Chinese herbal plant called Tsai-Fu.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Cheng JT, Tsai CL. Anti-inflammatory effect of saikogenin A. Biochem Pharmacol. 1986 Aug 1;35(15):2483-7. PubMed PMID: 2427082.

[2]Zeng B, Liu GD, Zhang BB, Wang SS, Ma R, Zhong BS, He BQ, Liang Y, Wu FH. A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze. Nat Prod Res. 2016;30(9):1001-8. doi: 10.1080/14786419.2015.1095745. Epub 2015 Oct 29. PubMed PMID: 26511166.

[3] Shibata S, Kitagawa I, Fujimoto H. The chemical studies on oriental plant drugs. XV. On the constituents of Bupleurum Spp. (2). The structure of saikogenin A, a sapogenin of Bupleurum falcatum L. Chem Pharm Bull (Tokyo). 1966 Sep;14(9):1023-33. PubMed PMID: 5976509.

[4] Shibata S, Kitagawa I, Fujimoto H. The structure of saikogenin A, a sapogenin of Bupleurum species. Tetrahedron Lett. 1965 Oct;(42):3783-8. PubMed PMID: 5842888.

[5] Kumazawa Y, Kawakita T, Takimoto H, Nomoto K. Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice. Int J Immunopharmacol. 1990;12(5):531-7. PubMed PMID: 2210914.

6: Nose M, Amagaya S, Ogihara Y. Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane. Chem Pharm Bull (Tokyo). 1989 Dec;37(12):3306-10. PubMed PMID: 2632076.7: Toriniwa Y, Lv X, Kodama Y, Ohizumi Y, Yoshida M, Nakahata N. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis. J Pharm Pharmacol. 2006 Jun;58(6):859-66. PubMed PMID: 16734988.8: Shibata M, Yoshida R, Motoashi S, Fukushima M. [Pharmacological studies on Bupleurum falcatum L. IV. Some pharmacological effects of crude saikosides, saikogenin A and syrupy residue (author's transl)]. Yakugaku Zasshi. 1973 Dec;93(12):1660-7. Japanese. PubMed PMID: 4798800.9: Shimizu K, Amagaya S, Ogihara Y. Structural transformation of saikosaponins by gastric juice and intestinal flora. J Pharmacobiodyn. 1985 Sep;8(9):718-25. PubMed PMID: 4087133.10: Kodama Y, Xiaochuan L, Tsuchiya C, Ohizumi Y, Yoshida M, Nakahata N. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells. Planta Med. 2003 Aug;69(8):765-7. PubMed PMID: 14531029.1

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