5092-09-1|Saikogenin A|(3S,4R,4aR,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol|-范德生物科技公司

Saikogenin A

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names：
(3S,4R,4aR,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol
CAS号：
5092-09-1
MDL Number：
MF(分子式)： C30H48O4 MW(分子量)： 472.71
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(3S,4R,4aR,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol
英文别名	Saikogenin A; Saikogenin D;
CAS号	5092-09-1
Inchi	InChI=1S/C30H48O4/c1-25(2)13-14-30(18-32)20(15-25)19-7-8-22-26(3)11-10-23(33)27(4,17-31)21(26)9-12-28(22,5)29(19,6)16-24(30)34/h7-8,21-24,31-34H,9-18H2,1-6H3/t21-,22-,23+,24+,26+,27+,28-,29-,30-/m1/s1
InchiKey	QGNVMEXLLPGQEV-HSFRRAFJSA-N
分子式 Formula	C30H48O4
分子量 Molecular Weight	472.71
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Saikogenin A(CAS:5092-09-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Saikogenin A is an anti-inflammatory drug that is present in the crude extract of a Chinese herbal plant called Tsai-Fu.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Cheng JT, Tsai CL. Anti-inflammatory effect of saikogenin A. Biochem Pharmacol. 1986 Aug 1;35(15):2483-7. PubMed PMID: 2427082.

[2]Zeng B, Liu GD, Zhang BB, Wang SS, Ma R, Zhong BS, He BQ, Liang Y, Wu FH. A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze. Nat Prod Res. 2016;30(9):1001-8. doi: 10.1080/14786419.2015.1095745. Epub 2015 Oct 29. PubMed PMID: 26511166.

[3] Shibata S, Kitagawa I, Fujimoto H. The chemical studies on oriental plant drugs. XV. On the constituents of Bupleurum Spp. (2). The structure of saikogenin A, a sapogenin of Bupleurum falcatum L. Chem Pharm Bull (Tokyo). 1966 Sep;14(9):1023-33. PubMed PMID: 5976509.

[4] Shibata S, Kitagawa I, Fujimoto H. The structure of saikogenin A, a sapogenin of Bupleurum species. Tetrahedron Lett. 1965 Oct;(42):3783-8. PubMed PMID: 5842888.

[5] Kumazawa Y, Kawakita T, Takimoto H, Nomoto K. Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice. Int J Immunopharmacol. 1990;12(5):531-7. PubMed PMID: 2210914.

6: Nose M, Amagaya S, Ogihara Y. Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane. Chem Pharm Bull (Tokyo). 1989 Dec;37(12):3306-10. PubMed PMID: 2632076.7: Toriniwa Y, Lv X, Kodama Y, Ohizumi Y, Yoshida M, Nakahata N. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis. J Pharm Pharmacol. 2006 Jun;58(6):859-66. PubMed PMID: 16734988.8: Shibata M, Yoshida R, Motoashi S, Fukushima M. [Pharmacological studies on Bupleurum falcatum L. IV. Some pharmacological effects of crude saikosides, saikogenin A and syrupy residue (author's transl)]. Yakugaku Zasshi. 1973 Dec;93(12):1660-7. Japanese. PubMed PMID: 4798800.9: Shimizu K, Amagaya S, Ogihara Y. Structural transformation of saikosaponins by gastric juice and intestinal flora. J Pharmacobiodyn. 1985 Sep;8(9):718-25. PubMed PMID: 4087133.10: Kodama Y, Xiaochuan L, Tsuchiya C, Ohizumi Y, Yoshida M, Nakahata N. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells. Planta Med. 2003 Aug;69(8):765-7. PubMed PMID: 14531029.1

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