132636-01-2|S 11568|3-ethyl 5-methyl 2-((2-(2-aminoethoxy)ethoxy)methyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride|-范德生物科技公司

S 11568

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names：
3-ethyl 5-methyl 2-((2-(2-aminoethoxy)ethoxy)methyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
CAS号：
132636-01-2
MDL Number：
MF(分子式)： C22H29Cl3N2O6 MW(分子量)： 523.83
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3-ethyl 5-methyl 2-((2-(2-aminoethoxy)ethoxy)methyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
英文别名	S 11568; S-11568; S11568; S 12968; S-12968; S12968;
CAS号	132636-01-2
Inchi	InChI=1S/C22H28Cl2N2O6.ClH/c1-4-32-22(28)19-16(12-31-11-10-30-9-8-25)26-13(2)17(21(27)29-3)18(19)14-6-5-7-15(23)20(14)24;/h5-7,18,26H,4,8-12,25H2,1-3H3;1H
InchiKey	CHEDLCOJOZRZRL-UHFFFAOYSA-N
分子式 Formula	C22H29Cl3N2O6
分子量 Molecular Weight	523.83
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	S 11568(CAS:132636-01-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	S 11568 is a dihydropyridine calcium channel antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Valette H, Dollé F, Guenther I, Hinnen F, Fuseau C, Coulon C, Péglion JL, Crouzel C. Myocardial kinetics of the (11)C-labeled enantiomers of the Ca(2+) channel inhibitor S11568: an in vivo study. J Nucl Med. 2001 Jun;42(6):932-7. PubMed PMID: 11390559.

[2]Dollé F, Valette H, Hinnen F, Fuseau C, Péglion JL, Crouzel C. Synthesis and characterization of a 11C-labelled derivative of S12968: an attempt to image in vivo brain calcium channels. Nucl Med Biol. 1998 May;25(4):339-42. PubMed PMID: 9639294.

[3] Dollé F, Hinnen F, Valette H, Fuseau C, Duval R, Péglion JL, Crouzel C. Synthesis of two optically active calcium channel antagonists labelled with carbon-11 for in vivo cardiac PET imaging. Bioorg Med Chem. 1997 Apr;5(4):749-64. PubMed PMID: 9158874.

[4] Valette H, Crouzel C, Syrota A, Fuseau C, Bourachot ML. Canine myocardial dihydropyridine binding sites: a positron emission tomographic study with the calcium channel inhibitor 11C-S11568. Life Sci. 1994;55(19):1471-7. PubMed PMID: 7968214.

[5] Morain P, Peglion JL, Giesen-Crouse E. Ca2+ channel inhibition in a rat osteoblast-like cell line, UMR 106, by a new dihydropyridine derivative, S11568. Eur J Pharmacol. 1992 Sep 10;220(1):11-7. PubMed PMID: 1385178.

6: Makki T, Lartaud I, Bray-des Boscs L, Capdeville-Atkinson C, Chillon JM, Hoffman M, Nicolas JP, Atkinson J. Haemodynamic effects of a new dihydropyridine calcium entry blocker, S-12968-(-), in a rat model of cardiovascular calcium overload. Br J Pharmacol. 1992 May;106(1):79-84. PubMed PMID: 1324069; PubMed Central PMCID: PMC1907437.7: Vilaine JP, Biondi ML, Villeneuve N, Feletou M, Peglion JL, Vanhoutte PM. The calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteries. Eur J Pharmacol. 1991 May 2;197(1):41-8. PubMed PMID: 1654260.8: Randle JC, Péglion JL, Renaud JF. Inhibition of L-type but not T-type calcium channel current by a new dihydropyridine derivative, S11568. J Cardiovasc Pharmacol. 1991 Feb;17(2):348-50. PubMed PMID: 1709243.9: Randle JC, Lombet A, Nagel N, Abraham C, Aptel H, Peglion JL, Renaud JF. Ca2+ channel inhibition by a new dihydropyridine derivative, S11568, and its enantiomers S12967 and S12968. Eur J Pharmacol. 1990 Nov 6;190(1-2):85-96. PubMed PMID: 1706275.

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