21794-01-4|Rubratoxin B|4-hydroxy-10-(hydroxy(6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl)-5-(1-hydroxyheptyl)-5,9,10,11-tetrahydro-1H-cyclonona[1,2-c5,6-c']difuran-1,3,6,8(4H)-tetraone|-范德生物科技公司

Rubratoxin B

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names：
4-hydroxy-10-(hydroxy(6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl)-5-(1-hydroxyheptyl)-5,9,10,11-tetrahydro-1H-cyclonona[1,2-c5,6-c']difuran-1,3,6,8(4H)-tetraone
CAS号：
21794-01-4
MDL Number：
MF(分子式)： C26H30O11 MW(分子量)： 518.51
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	4-hydroxy-10-(hydroxy(6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl)-5-(1-hydroxyheptyl)-5,9,10,11-tetrahydro-1H-cyclonona[1,2-c5,6-c']difuran-1,3,6,8(4H)-tetraone
英文别名	Rubratoxin B;
CAS号	21794-01-4
SMILES	O=C(C1=C2C(O)C(C(O)CCCCCC)C3=C(CC(C(C4CC=CC(O4)=O)O)C1)C(OC3=O)=O)OC2=O
Inchi	InChI=1S/C26H30O11/c1-2-3-4-5-7-15(27)20-18-13(23(31)36-25(18)33)10-12(21(29)16-8-6-9-17(28)35-16)11-14-19(22(20)30)26(34)37-24(14)32/h6,9,12,15-16,20-22,27,29-30H,2-5,7-8,10-11H2,1H3
InchiKey	ZJTBTDVZNGBSNG-UHFFFAOYSA-N
分子式 Formula	C26H30O11
分子量 Molecular Weight	518.51
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Rubratoxin B(CAS:21794-01-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has shown anticancer activity.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nagashima H. Rubratoxin-B-induced secretion of chemokine ligands of cysteine-cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells. Environ Toxicol Pharmacol. 2015 Nov;40(3):997-1000. doi: 10.1016/j.etap.2015.10.012. Epub 2015 Nov 2. PubMed PMID: 26595743.

[2]Iwashita K, Nagashima H. Rubratoxin B induces signs of fatty acid oxidation disorders (FAODs) in mice. Toxicol Lett. 2011 Oct 10;206(2):238-43. doi: 10.1016/j.toxlet.2011.07.027. Epub 2011 Jul 30. PubMed PMID: 21835235.

[3] Nagashima H, Nakamura K, Goto T. Hepatotoxin rubratoxin B induced the secretion of TNF-alpha, IL-8, and MCP-1 in HL60 cells. Biochem Biophys Res Commun. 2001 Oct 5;287(4):829-32. PubMed PMID: 11573937.

[4] Iwashita K, Nagashima H. Rubratoxin B induces interleukin-6 secretion in mouse white adipose tissues and 3T3-L1 adipocytes. Toxicol Lett. 2008 Nov 10;182(1-3):79-83. doi: 10.1016/j.toxlet.2008.08.008. Epub 2008 Aug 29. PubMed PMID: 18804154.

[5] Nagashima H, Nakamura K, Goto T. Rubratoxin B induced the secretion of hepatic injury-related colony stimulating factors in human hepatoma cells. Toxicol Lett. 2003 Nov 30;145(2):153-9. PubMed PMID: 14581167.

6: Phillips TD, Hayes AW. Structural modification of polyfunctional rubratoxin B: effects on mammalian adenosine triphosphatase. J Environ Pathol Toxicol. 1979 Jan-Feb;2(3):853-60. PubMed PMID: 217944.7: Nagashima H, Maeda-Nakamura K, Iwashita K, Goto T. Induced secretion of insulin-like growth factor binding protein-1 (IGFBP-1) in human hepatoma cell HepG2 by rubratoxin B. Arch Toxicol. 2007 May;81(5):347-51. Epub 2006 Nov 16. PubMed PMID: 17109117.8: Unger PD, Hayes AW. High-pressure liquid chromatography of the mycotoxins, rubratoxins A and B, and its application to the analysis of urine and plasma for rubratoxin B. J Chromatogr. 1978 Jun 1;153(1):115-26. PubMed PMID: 580783.9: Nagashima H, Nakamura K, Goto T. Stress-activated MAP kinases regulate rubratoxin B-caused cytotoxicity and cytokine secretion in hepatocyte-derived HepG2 cells. Toxicol Lett. 2005 Feb 15;155(2):259-67. PubMed PMID: 15603921.10: Wang T, Zhang Y, Wang Y, Pei YH. Anti-tumor effects of Rubratoxin B on cell toxicity, inhibition of cell proliferation, cytotoxic activity and matrix metalloproteinase-2,9. Toxicol In Vitro. 2007 Jun;21(4):646-50. Epub 2007 Jan 11. PubMed PMID: 17306501.1

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