850807-63-5|RSM-932A|1,1'-([1,1'-biphenyl]-4,4'-diylbis(methylene))bis(4-((4-chlorophenyl)(methyl)amino)quinolin-1-ium) bromide|-范德生物科技公司

RSM-932A

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names：
1,1'-([1,1'-biphenyl]-4,4'-diylbis(methylene))bis(4-((4-chlorophenyl)(methyl)amino)quinolin-1-ium) bromide
CAS号：
850807-63-5
MDL Number：
MF(分子式)： C46H38Br2Cl2N4 MW(分子量)： 877.546
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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FMK18895-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	1,1'-([1,1'-biphenyl]-4,4'-diylbis(methylene))bis(4-((4-chlorophenyl)(methyl)amino)quinolin-1-ium) bromide
英文别名	RSM-932A; RSM 932A; RSM932A; TCD 717; TCD717; TCD-717.
CAS号	850807-63-5
Inchi	InChI=1S/C46H38Cl2N4.2BrH/c1-49(39-23-19-37(47)20-24-39)43-27-29-51(45-9-5-3-7-41(43)45)31-33-11-15-35(16-12-33)36-17-13-34(14-18-36)32-52-30-28-44(42-8-4-6-10-46(42)52)50(2)40-25-21-38(48)22-26-40;;/h3-30H,31-32H2,1-2H3;2*1H/q+2;;/p-2
InchiKey	DGBVSSXGHKAASQ-UHFFFAOYSA-L
分子式 Formula	C46H38Br2Cl2N4
分子量 Molecular Weight	877.546
溶解度Solubility
性状	White solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RSM-932A(CAS:850807-63-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RSM-932A, also known as TCD-717, is a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A appears to have an altogether novel mechanism of inhibition and is synergistic with respect to both choline and ATP. RSM-932A have in vitro inhibitory activity in the low nanomolar range. RSM-932A significantly reduced parasitemia and induced the accumulation of trophozoites and schizonts, blocking intraerythrocytic development and interfering with parasite egress or invasion, suggesting a delay of the parasite maturation stage.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lacal JC, Campos JM. Preclinical characterization of RSM-932A, a novelanticancer drug targeting the human choline kinase alpha, an enzyme involved inincreased lipid metabolism of cancer cells. Mol Cancer Ther. 2015 Jan;14(1):31-9.doi: 10.1158/1535-7163.MCT-14-053[1]Epub 2014 Dec 8. PubMed PMID: 25487918.

[2]Zimmerman T, Moneriz C, Diez A, Bautista JM, Gómez Del Pulgar T, Cebrián A,Lacal JC. Antiplasmodial activity and mechanism of action of RSM-932A, apromising synergistic inhibitor of Plasmodium falciparum choline kinase.Antimicrob Agents Chemother. 2013 Dec;57(12):5878-88. doi: 10.1128/AAC.00920-13.Epub 2013 Sep 16. PubMed PMID: 24041883; PubMed Central PMCID: PMC3837925.

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