300561-61-9|(R)-SCH-23982 HCl|(R)-2,3,4,5-Tetrahydro-8-hydroxy-3-methyl-1-phenyl-1H-3-benzazepine|-范德生物科技公司

(R)-SCH-23982 HCl

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names：
(R)-2,3,4,5-Tetrahydro-8-hydroxy-3-methyl-1-phenyl-1H-3-benzazepine
CAS号：
300561-61-9
MDL Number：
MF(分子式)： C17H19NO MW(分子量)： 253.34
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(R)-2,3,4,5-Tetrahydro-8-hydroxy-3-methyl-1-phenyl-1H-3-benzazepine
英文别名	(R)-SCH-23982 HCl; (R)SCH23982 HCl; (R) SCH 23982 HCl; R-SCH-23982 HCl; (R) SCH 23982 Hydrochloride; (R)SCH23982 Hydrochloride; (R)-(+)-Deschloro-SCH23390 HCl;
CAS号	300561-61-9
Inchi	InChI=1S/C17H19NO/c1-18-10-9-14-7-8-15(19)11-16(14)17(12-18)13-5-3-2-4-6-13/h2-8,11,17,19H,9-10,12H2,1H3/t17-/m1/s1
InchiKey	DNNMNDDMPUSDQC-QGZVFWFLSA-N
分子式 Formula	C17H19NO
分子量 Molecular Weight	253.34
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	(R)-SCH-23982 HCl(CAS:300561-61-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	(R)-SCH-23982 HCl is a D1 antagonist and a precursor of [125I]-(R)-SCH-23982.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Shin Y, White BH, Uh M, Sidhu A. Modulation of D1-like dopamine receptor function by aldehydic products of lipid peroxidation. Brain Res. 2003 Apr 4;968(1):102-13. PubMed PMID: 12644268.

[2]Sidhu A, Olde B, Humblot N, Kimura K, Gardner N. Regulation of human D1 dopamine receptor function and gene expression in SK-N-MC neuroblastoma cells. Neuroscience. 1999;91(2):537-47. PubMed PMID: 10366011.

[3] Sidhu A, Uh M, Sela S, White BH, Kimura K, Patel S. Molecular and structural differences between rat brain D-1 and renal DA-1 dopamine receptors. Neurosci Res. 1997 Sep;29(1):1-8. PubMed PMID: 9293487.

[4] Lawler CP, Gilmore JH, Mooney DH, Mayleben MA, Atashi JR, Mileson BE, Wyrick SD, Mailman RB. A rapid and efficient method for the radiosynthesis and purification of [125I]SCH23982. J Neurosci Methods. 1993 Aug;49(1-2):141-53. PubMed PMID: 8271827.

[5] Sidhu A, Vachvanichsanong P, Jose PA, Felder RA. Persistent defective coupling of dopamine-1 receptors to G proteins after solubilization from kidney proximal tubules of hypertensive rats. J Clin Invest. 1992 Mar;89(3):789-93. PubMed PMID: 1531836; PubMed Central PMCID: PMC442923.

6: Sidhu A. A novel affinity purification of D-1 dopamine receptors from rat striatum. J Biol Chem. 1990 Jun 15;265(17):10065-72. PubMed PMID: 2141020.7: Sidhu A, Felder RA, Jose PA, Fishman PH. Comparison of the central and renal dopamine-1 receptor. Am J Hypertens. 1990 Jun;3(6 Pt 2):37S-39S. PubMed PMID: 1974441.8: Sidhu A, Fishman PH. Identification and characterization of functional D1 dopamine receptors in a human neuroblastoma cell line. Biochem Biophys Res Commun. 1990 Jan 30;166(2):574-9. PubMed PMID: 2154212.9: Sidhu A. Solubilization and reconstitution of the D-1 dopamine receptor: potentiation of the agonist high-affinity state of the receptor. Biochemistry. 1988 Nov 29;27(24):8768-76. PubMed PMID: 2977287.10: Kung HF, Billings JJ, Guo YZ, Blau M, Ackerhalt R. Preparation and biodistribution of [125I]IBZP: a potential CNS D-1 dopamine receptor imaging agent. Int J Rad Appl Instrum B. 1988;15(2):187-93. PubMed PMID: 2966781.1

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