57452-98-9|(R)-Praziquantel|(11bR)-2-(Cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one|-范德生物科技公司

(R)-Praziquantel

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names：
(11bR)-2-(Cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
CAS号：
57452-98-9
MDL Number：
MF(分子式)： C19H24N2O2 MW(分子量)： 312.41
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(11bR)-2-(Cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
英文别名	(R)-Praziquantel; (R)Praziquantel; (R) Praziquantel; R-Praziquantel; R Praziquantel; (R)-PZQ; (R) PZQ; (R)PZQ; (-)-Praziquantel; (-) Praziquantel; arpraziquantel
CAS号	57452-98-9
Inchi	InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2/t17-/m0/s1
InchiKey	FSVJFNAIGNNGKK-KRWDZBQOSA-N
分子式 Formula	C19H24N2O2
分子量 Molecular Weight	312.41
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	(R)-Praziquantel(CAS:57452-98-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	(R)-Praziquantel is an active enantiomer of praziquantel that acts as a potent anthelmintic.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bowman DD, Drake J. Examination of the "susceptibility gap" in the treatment of canine heartworm infection. Parasit Vectors. 2017 Nov 9;10(Suppl 2):513. doi: 10.1186/s13071-017-2433-9. Review. PubMed PMID: 29143689; PubMed Central PMCID: PMC5688481.

[2]da Silva VBR, Campos BRKL, de Oliveira JF, Decout JL, do Carmo Alves de Lima M. Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine. Bioorg Med Chem. 2017 Jul 1;25(13):3259-3277. doi: 10.1016/j.bmc.2017.04.031. Epub 2017 Apr 27. Review. PubMed PMID: 28495384.

[3] Bustinduy AL, Wright S, Joekes EC, Kabatereine NB, Reinhard-Rupp J, King CH, Stothard JR. One hundred years of neglect in paediatric schistosomiasis. Parasitology. 2017 Oct;144(12):1613-1623. doi: 10.1017/S0031182017000014. Epub 2017 Mar 1. Review. PubMed PMID: 28245890.

[4] Price A, Verma A, Welfare W. Are health education interventions effective for the control and prevention of urogenital schistosomiasis in sub-Saharan Africa? A systematic review. Trans R Soc Trop Med Hyg. 2015 Apr;109(4):239-44. doi: 10.1093/trstmh/trv008. Epub 2015 Feb 10. Review. PubMed PMID: 25669840.

[5] Olliaro P, Delgado-Romero P, Keiser J. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer). J Antimicrob Chemother. 2014 Apr;69(4):863-70. doi: 10.1093/jac/dkt491. Epub 2014 Jan 2. Review. PubMed PMID: 24390933.

6: Xiao SH, Keiser J, Chen MG, Tanner M, Utzinger J. Research and development of antischistosomal drugs in the People's Republic of China a 60-year review. Adv Parasitol. 2010;7

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