170902-47-3|Roxifiban|methyl (S)-2-((butoxycarbonyl)amino)-3-(2-((R)-3-(4-carbamimidoylphenyl)-4,5-dihydroisoxazol-5-yl)acetamido)propanoate|-范德生物科技公司

Roxifiban

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names：
methyl (S)-2-((butoxycarbonyl)amino)-3-(2-((R)-3-(4-carbamimidoylphenyl)-4,5-dihydroisoxazol-5-yl)acetamido)propanoate
CAS号：
170902-47-3
MDL Number：
MF(分子式)： C21H29N5O6 MW(分子量)： 447.49
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	methyl (S)-2-((butoxycarbonyl)amino)-3-(2-((R)-3-(4-carbamimidoylphenyl)-4,5-dihydroisoxazol-5-yl)acetamido)propanoate
英文别名	Roxifiban; DMP754; DMP 754; DMP-754;
CAS号	170902-47-3
Inchi	InChI=1S/C21H29N5O6/c1-3-4-9-31-21(29)25-17(20(28)30-2)12-24-18(27)11-15-10-16(26-32-15)13-5-7-14(8-6-13)19(22)23/h5-8,15,17H,3-4,9-12H2,1-2H3,(H3,22,23)(H,24,27)(H,25,29)/t15-,17+/m1/s1
InchiKey	IRAXRQFCCSHQDX-WBVHZDCISA-N
分子式 Formula	C21H29N5O6
分子量 Molecular Weight	447.49
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Roxifiban(CAS:170902-47-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Roxifiban is a prodrug whose methyl-ester is hydrolysed following oral adminstration to form the GPIIb/GPIIIA antagonist XV459.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Christen JR, Soubrier C, Martinez E, Roumieu V, Darmon O, Scandaliaris S, Picou L, Cuisset T, Grados A, Bernit E, Ebbo M, Harlé JR, Schleinitz N. [Long-lasting thrombocytopenia induced by glycoprotein IIb/IIIa inhibitor]. Rev Med Interne. 2017 Nov;38(11):769-773. doi: 10.1016/j.revmed.2017.05.013. Epub 2017 Jul 6. French. PubMed PMID: 28690092.

[2]Hantgan RR, Stahle MC. Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta

[3]PAC-1 molecular recognition. Biochemistry. 2009 Sep 8;48(35):8355-65. doi: 10.1021/bi900475k. PubMed PMID: 19640007.

[4]Barrett YC, Ebling W, Pieniaszek H, Billheimer J, Seiffert D. Validation and implementation of drug-dependent antibody assays in clinical trials for safety monitoring of patients dosed with roxifiban, an orally bioavailable glycoprotein IIb/IIIa antagonist. J Pharm Biomed Anal. 2007 Aug 15;44(4):938-46. Epub 2007 Mar 31. PubMed PMID: 17485191.

[5] Mousa SA. In-vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists and thrombolytics on platelet/fibrin-mediated clot dynamics in human whole blood using thrombelastography. Blood Coagul Fibrinolysis. 2007 Jan;18(1):55-60. PubMed PMID: 17179828.

5: Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA. AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists. J Thromb Haemost. 2007 Mar;5(3):542-50. Epub 2006 Dec 13. PubMed PMID: 17166246.

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