135357-96-9|Restricticin|(2R,3S,4R,5R)-2-((2E,4E,6E)-deca-2,4,6-trien-2-yl)-4-methoxy-5-methyltetrahydro-2H-pyran-3-yl glycinate|-范德生物科技公司

Restricticin

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names：
(2R,3S,4R,5R)-2-((2E,4E,6E)-deca-2,4,6-trien-2-yl)-4-methoxy-5-methyltetrahydro-2H-pyran-3-yl glycinate
CAS号：
135357-96-9
MDL Number：
MF(分子式)： C19H31NO4 MW(分子量)： 337.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(2R,3S,4R,5R)-2-((2E,4E,6E)-deca-2,4,6-trien-2-yl)-4-methoxy-5-methyltetrahydro-2H-pyran-3-yl glycinate
英文别名	Restricticin; Ro 09-1470; Ro-09-1470; Ro09-1470;
CAS号	135357-96-9
SMILES	NCC(O[C@@H]1[C@@H](/C(C)=C/C=C/C=C/CCC)OC[C@@H](C)[C@H]1OC)=O
Inchi	InChI=1S/C19H31NO4/c1-5-6-7-8-9-10-11-14(2)18-19(24-16(21)12-20)17(22-4)15(3)13-23-18/h7-11,15,17-19H,5-6,12-13,20H2,1-4H3/b8-7+,10-9+,14-11+/t15-,17-,18-,19+/m1/s1
InchiKey	FIFAQBUMNRZWOQ-OVBFOOSGSA-N
分子式 Formula	C19H31NO4
分子量 Molecular Weight	337.46
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Restricticin(CAS:135357-96-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Restricticin is a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Schwartz RE, Dufresne C, Flor JE, Kempf AJ, Wilson KE, Lam T, Onishi J, Milligan J, Fromtling RA, Abruzzo GK, et al. Restricticin, a novel glycine-containing antifungal agent. J Antibiot (Tokyo). 1991 May;44(5):463-7[1]PubMed PMID: 2061189.

[2]VanMiddlesworth F, Milligan J, Bartizal K, Dufresne C, Onishi J, Abruzzo G, Patchett A, Wilson K. Carbazate as a glycine bioisostere in restricticin. J Antibiot (Tokyo). 1996 Mar;49(3):329-31. PubMed PMID: 8626254.

[3] Tsukuda T, Watanabe M, Ontsuka H, Hattori K, Shirai M, Shimma N. Synthesis of novel antifungal agents (2). Bioorg Med Chem Lett. 1998 Jul 21;8(14):1825-8. PubMed PMID: 9873441.

[4] Tsukuda T, Shiratori Y, Watanabe M, Ontsuka H, Hattori K, Shirai M, Shimma N. Modeling, synthesis and biological activity of novel antifungal agents (1). Bioorg Med Chem Lett. 1998 Jul 21;8(14):1819-24. PubMed PMID: 9873440.

[5] Barrett AG, Bennett AJ, Menzer S, Smith ML, White AJ, Williams DJ. Applications of Crotonyldiisopinocampheylboranes in Synthesis: Total Synthesis of Restrictinol. J Org Chem. 1999 Jan 8;64(1):162-171. PubMed PMID: 11674099.

6: Aoki Y, Yoshihara F, Kondoh M, Nakamura Y, Nakayama N, Arisawa M. Ro 09-1470 is a selective inhibitor of P-450 lanosterol C-14 demethylase of fungi. Antimicrob Agents Chemother. 1993 Dec;37(12):2662-7. PubMed PMID: 8109933; PubMed Central PMCID: PMC192771.7: Aoki Y, Yamazaki T, Kondoh M, Sudoh Y, Nakayama N, Sekine Y, Shimada H, Arisawa M. A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. II. Mode of action. J Antibiot (Tokyo). 1992 Feb;45(2):160-70. PubMed PMID: 1556007.8: Matsukuma S, Ohtsuka T, Kotaki H, Shirai H, Sano T, Watanabe K, Nakayama N, Itezono Y, Fujiu M, Shimma N, et al. A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. I. Taxonomy, fermentation, isolation and structural elucidation. J Antibiot (Tokyo). 1992 Feb;45(2):151-9. PubMed PMID: 1556006.

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