661472-41-9|Relamorelin|N-((R)-3-(benzo[b]thiophen-3-yl)-1-(((R)-1-(((S)-1-((4-carbamoylpiperidin-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)piperidine-3-carboxamide|-范德生物科技公司

Relamorelin

NMR下载 COA and HPLC MSDS下载
names：
N-((R)-3-(benzo[b]thiophen-3-yl)-1-(((R)-1-(((S)-1-((4-carbamoylpiperidin-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)piperidine-3-carboxamide
CAS号：
661472-41-9
MDL Number：
MF(分子式)： C43H50N8O5S MW(分子量)： 790.984
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK18535-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	N-((R)-3-(benzo[b]thiophen-3-yl)-1-(((R)-1-(((S)-1-((4-carbamoylpiperidin-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)piperidine-3-carboxamide
英文别名	BIM28131; BIM 28131; BIM-28131; BIM-28163; BIM 28163; BIM28163; RM131; RM-131; RM 131; Relamorelin
CAS号	661472-41-9
Inchi	InChI=1S/C43H50N8O5S/c44-42(56)43(16-19-45-20-17-43)51-41(55)34(21-27-9-2-1-3-10-27)49-39(53)35(22-29-25-47-33-14-6-4-12-31(29)33)50-40(54)36(48-38(52)28-11-8-18-46-24-28)23-30-26-57-37-15-7-5-13-32(30)37/h1-7,9-10,12-15,25-26,28,34-36,45-47H,8,11,16-24H2,(H2,44,56)(H,48,52)(H,49,53)(H,50,54)(H,51,55)/t28?,34-,35+,36+/m0/s1
InchiKey	IPMQOGDSJZQLFX-BIBZJUPHSA-N
分子式 Formula	C43H50N8O5S
分子量 Molecular Weight	790.984
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Relamorelin(CAS:661472-41-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Relamorelin, also known as BIM28131 and RM131, is a centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) potentially useful for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. It is a pentapeptide and analogue of ghrelin with improved potency and pharmacokinetics. In humans, relamorelin produces increases in plasma growth hormone, prolactin, and cortisol levels, and, like other GHSR agonists, increases appetite.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Camilleri M. Novel Diet, Drugs and Gastric Interventions for Gastroparesis. Clin Gastroenterol Hepatol. 2016 Jan 4. pii: S1542-3565(15)01724-3. doi: 10.1016/j.cgh.2015.12.033. [Epub ahead of print] Review. PubMed PMID: 26762845.

[2]Bassotti G. Relamorelin to Treat Constipation: "Pusher" or Pushover? Dig Dis Sci. 2015 Oct 24. [Epub ahead of print] PubMed PMID: 26500115.

[3] Acosta A, Camilleri M, Busciglio I, Boldingh A, Nelson AD, Burton D. Short-Term Effects of Relamorelin on Descending Colon Motility in Chronic Constipation: A Randomized, Controlled Trial. Dig Dis Sci. 2015 Oct 14. [Epub ahead of print] PubMed PMID: 26467700.

[4] Sanger GJ, Furness JB. Ghrelin and motilin receptors as drug targets for gastrointestinal disorders. Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):38-48. doi: 10.1038/nrgastro.2015.163. Epub 2015 Sep 22. Review. PubMed PMID: 26392067.

[5] Acosta A, Camilleri M, Kolar G, Iturrino J, Szarka LA, Boldingh A, Burton D, Ryks M, Rhoten D, Zinsmeister AR, Spence SC, Gottesdiener K, Bouras EP, Vazquez-Roque MI. Relamorelin Relieves Constipation and Accelerates Colonic Transit in a Phase 2, Placebo-Controlled, Randomized Trial. Clin Gastroenterol Hepatol. 2015 Dec;13(13):2312-2319.e1. doi: 10.1016/j.cgh.2015.04.184. Epub 2015 May 19. PubMed PMID: 26001337.

6: Shin A, Wo JM. Therapeutic applications of ghrelin agonists in the treatment of gastroparesis. Curr Gastroenterol Rep. 2015 Feb;17(2):430. doi: 10.1007/s11894-015-0430-8. Review. PubMed PMID: 25702264.7: Acosta A, Camilleri M. Prokinetics in gastroparesis. Gastroenterol Clin North Am. 2015 Mar;44(1):97-111. doi: 10.1016/j.gtc.2014.11.008. Epub 2014 Dec 23. Review. PubMed PMID: 25667026.8: Camilleri M, Acosta A. Emerging treatments in Neurogastroenterology: relamorelin: a novel gastrocolokinetic synthetic ghrelin agonist. Neurogastroenterol Motil. 2015 Mar;27(3):324-32. doi: 10.1111/nmo.12490. Epub 2014 Dec 29. Review. PubMed PMID: 25545036; PubMed Central PMCID: PMC4424792.9: Peeters TL. Gastrointestinal hormones and gut motility. Curr Opin Endocrinol Diabetes Obes. 2015 Feb;22(1):9-13. doi: 10.1097/MED.0000000000000123. Review. PubMed PMID: 25517024.10: Palus S, von Haehling S, Doehner W, Datta R, Zhang J, Dong JZ, Culler MD, Anker SD, Springer J. Effect of application route of the ghrelin analog BIM-28131 (RM-131) on body weight and body composition in a rat heart failure model. Int J Cardiol. 2013 Oct 3;168(3):2369-74. doi: 10.1016/j.ijcard.2013.01.263. Epub 2013 Mar 7. PubMed PMID: 23465234.

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