135949-60-9|RB 101|benzyl (3-((2-amino-4-(methylthio)butyl)disulfanyl)-2-benzylpropanoyl)-L-phenylalaninate|-范德生物科技公司

RB 101

NMR下载 COA and HPLC MSDS下载
names：
benzyl (3-((2-amino-4-(methylthio)butyl)disulfanyl)-2-benzylpropanoyl)-L-phenylalaninate
CAS号：
135949-60-9
MDL Number：
MF(分子式)： C31H38N2O3S3 MW(分子量)： 582.83
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	benzyl (3-((2-amino-4-(methylthio)butyl)disulfanyl)-2-benzylpropanoyl)-L-phenylalaninate
英文别名	RB 101; RB-101; RB101;
CAS号	135949-60-9
Inchi	InChI=1S/C31H38N2O3S3/c1-37-18-17-28(32)23-39-38-22-27(19-24-11-5-2-6-12-24)30(34)33-29(20-25-13-7-3-8-14-25)31(35)36-21-26-15-9-4-10-16-26/h2-16,27-29H,17-23,32H2,1H3,(H,33,34)/t27?,28?,29-/m0/s1
InchiKey	QXXMSEVVNUSHKJ-PPUMFKDSSA-N
分子式 Formula	C31H38N2O3S3
分子量 Molecular Weight	582.83
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RB 101(CAS:135949-60-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RB 101 inhibits enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Jayaram A, Singh P, Noreuil T, Fournié-Zaluski MC, Carp HM. RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice. Anesth Analg. 1997 Feb;84(2):355-8. PubMed PMID: 9024028.

[2]Coudoré-Civiale MA, Méen M, Fournié-Zaluski MC, Boucher M, Roques BP, Eschalier A. Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats. Br J Pharmacol. 2001 May;133(1):179-85. PubMed PMID: 11325808; PubMed Central PMCID: PMC1572770.

[3] Ruiz F, Fournié-Zaluski MC, Roques BP, Maldonado R. Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism. Br J Pharmacol. 1996 Sep;119(1):174-82. PubMed PMID: 8872371; PubMed Central PMCID: PMC1915744.

[4] Baamonde A, Daugé V, Ruiz-Gayo M, Fulga IG, Turcaud S, Fournié-Zaluski MC, Roques BP. Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation. Eur J Pharmacol. 1992 Jun 5;216(2):157-66. PubMed PMID: 1327810.

[5] Maldonado R, Valverde O, Ducos B, Blommaert AG, Fournie-Zaluski MC, Roques BP. Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308. Br J Pharmacol. 1995 Mar;114(5):1031-9. PubMed PMID: 7780637; PubMed Central PMCID: PMC1510310.

6: Ortega-Alvaro A, Chover-Gonzalez AJ, Lai-Kuen R, Mico JA, Gibert-Rahola J, Fournié-Zaluski MC, Roques BP, Maldonado R. Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord. Eur J Pharmacol. 1998 Sep 4;356(2-3):139-48. PubMed PMID: 9774243.7: Ruiz-Gayo M, Baamonde A, Turcaud S, Fournie-Zaluski MC, Roques BP. In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding. Brain Res. 1992 Feb 7;571(2):306-12. PubMed PMID: 1319268.8: Kolosova LI, Moiseeva AB, Riabchikova OV, Akoev GN. [Effect of RB-101, inhibitor of enkephalin degrading enzymes, on recovery of conductivity of the injured sciatic nerve in rats]. Ross Fiziol Zh Im I M Sechenova. 1997 Nov-Dec;83(11-12):74-8. Russian. PubMed PMID: 9541959.9: Noble F, Coric P, Turcaud S, Fournié-Zaluski MC, Roques BP. Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101. Eur J Pharmacol. 1994 Mar 3;253(3):283-7. PubMed PMID: 8200422.10: Maldonado R, Derrien M, Noble F, Roques BP. Association of the peptidase inhibitor RB 101 and a CCK-B antagonist strongly enhances antinociceptive responses. Neuroreport. 1993 Jul;4(7):947-50. PubMed PMID: 8369487.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开