74622-75-6|Ravidomycin|(2R,3R,4R,5R,6S)-4-(dimethylamino)-5-hydroxy-6-(1-hydroxy-10,12-dimethoxy-6-oxo-8-vinyl-6H-dibenzo[c,h]chromen-4-yl)-2-methyltetrahydro-2H-pyran-3-yl acetate|-范德生物科技公司

Ravidomycin

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names：
(2R,3R,4R,5R,6S)-4-(dimethylamino)-5-hydroxy-6-(1-hydroxy-10,12-dimethoxy-6-oxo-8-vinyl-6H-dibenzo[c,h]chromen-4-yl)-2-methyltetrahydro-2H-pyran-3-yl acetate
CAS号：
74622-75-6
MDL Number：
MF(分子式)： C31H33NO9 MW(分子量)： 563.6
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(2R,3R,4R,5R,6S)-4-(dimethylamino)-5-hydroxy-6-(1-hydroxy-10,12-dimethoxy-6-oxo-8-vinyl-6H-dibenzo[c,h]chromen-4-yl)-2-methyltetrahydro-2H-pyran-3-yl acetate
英文别名	Ravidomycin; AY 25545; AY-25545; AY25545;
CAS号	74622-75-6
Inchi	InChI=1S/C31H33NO9/c1-8-16-11-19-23(21(12-16)37-6)18-13-22(38-7)25-20(34)10-9-17(24(25)29(18)41-31(19)36)30-27(35)26(32(4)5)28(14(2)39-30)40-15(3)33/h8-14,26-28,30,34-35H,1H2,2-7H3/t14-,26-,27-,28+,30+/m1/s1
InchiKey	GHLIFBNIGXVDHM-LSXWJJIVSA-N
分子式 Formula	C31H33NO9
分子量 Molecular Weight	563.6
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ravidomycin(CAS:74622-75-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ravidomycin is an antitumor antibiotic. It exhibits potent anticancer activities against various cancer cell lines in the presence of visible light.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kharel MK, Nybo SE, Shepherd MD, Rohr J. Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters. Chembiochem. 2010 Mar 1;11(4):523-32. doi: 10.1002/cbic.200900673. PubMed PMID: 20140934; PubMed Central PMCID: PMC2879346.

[2]Sehgal SN, Czerkawski H, Kudelski A, Pandev K, Saucier R, Vézina C. Ravidomycin (AY-25,545), a new antitumor antibiotic. J Antibiot (Tokyo). 1983 Apr;36(4):355-61. PubMed PMID: 6853365.

[3] Rakhit S, Eng C, Baker H, Singh K. Chemical modification of ravidomycin and evaluation of biological activities of its derivatives. J Antibiot (Tokyo). 1983 Nov;36(11):1490-4. PubMed PMID: 6654759.

[4] Singh K. Studies on the mechanism of action of ravidomycin (AY-25,545). J Antibiot (Tokyo). 1984 Jan;37(1):71-3. PubMed PMID: 6421790.

[5] Greenstein M, Monji T, Yeung R, Maiese WM, White RJ. Light-dependent activity of the antitumor antibiotics ravidomycin and desacetylravidomycin. Antimicrob Agents Chemother. 1986 May;29(5):861-6. PubMed PMID: 3729344; PubMed Central PMCID: PMC284168.

6: Kharel MK, Lian H, Rohr J. Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate. Org Biomol Chem. 2011 Mar 21;9(6):1799-808. doi: 10.1039/c0ob00854k. Epub 2011 Jan 24. PubMed PMID: 21264378; PubMed Central PMCID: PMC4482361.7: Yamashita N, Shin-ya K, Furihata K, Hayakawa Y, Seto H. New ravidomycin analogues, FE35A and FE35B, apoptosis inducers produced by Streptomyces rochei. J Antibiot (Tokyo). 1998 Dec;51(12):1105-8. PubMed PMID: 10048570.8: Kharel MK, Pahari P, Lian H, Rohr J. Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic. Org Lett. 2010 Jun 18;12(12):2814-7. doi: 10.1021/ol1009009. PubMed PMID: 20486694; PubMed Central PMCID: PMC2895501.9: Kharel MK, Pahari P, Shepherd MD, Tibrewal N, Nybo SE, Shaaban KA, Rohr J. Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis. Nat Prod Rep. 2012 Feb;29(2):264-325. doi: 10.1039/c1np00068c. Epub 2011 Dec 21. Review. PubMed PMID: 22186970.10: Narita T, Matsumoto M, Mogi K, Kukita K, Kawahara R, Nakashima T. Deacetylravidomycin N-oxide, a new antibiotic. Taxonomy and fermentation of the producing organism and isolation, structure and biological properties of the antibiotic. J Antibiot (Tokyo). 1989 Mar;42(3):347-56. PubMed PMID: 2708127.1

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