100241-46-1|R 61837|3-methoxy-6-(4-(m-tolyl)piperazin-1-yl)pyridazine|-范德生物科技公司

R 61837

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names：
3-methoxy-6-(4-(m-tolyl)piperazin-1-yl)pyridazine
CAS号：
100241-46-1
MDL Number：
MF(分子式)： C16H20N4O MW(分子量)： 284.36
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3-methoxy-6-(4-(m-tolyl)piperazin-1-yl)pyridazine
英文别名	R 61837; R-61837; R61837;
CAS号	100241-46-1
SMILES	CC1=CC(N2CCN(C3=NN=C(OC)C=C3)CC2)=CC=C1
Inchi	InChI=1S/C16H20N4O/c1-13-4-3-5-14(12-13)19-8-10-20(11-9-19)15-6-7-16(21-2)18-17-15/h3-7,12H,8-11H2,1-2H3
InchiKey	DDOAUTHWSCUHQA-UHFFFAOYSA-N
分子式 Formula	C16H20N4O
分子量 Molecular Weight	284.36
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	R 61837(CAS:100241-46-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	R 61837 is an antirhinoviral agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Andries K, Dewindt B, Snoeks J, Willebrords R, van Eemeren K, Stokbroekx R, Janssen PA. In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity. Antimicrob Agents Chemother. 1992 Jan;36(1):100-7. PubMed PMID: 1317142; PubMed Central PMCID: PMC189235.

[2]Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K. Human rhinovirus 14 complexed with antiviral compound R 61837. J Mol Biol. 1991 Feb 5;217(3):455-63. PubMed PMID: 1847215.

[3] Andries K, Dewindt B, De Brabander M, Stokbroekx R, Janssen PA. In vitro activity of R 61837, a new antirhinovirus compound. Arch Virol. 1988;101(3-4):155-67. PubMed PMID: 2845889.

[4] Dewindt B, van Eemeren K, Andries K. Antiviral capsid-binding compounds can inhibit the adsorption of minor receptor rhinoviruses. Antiviral Res. 1994 Sep;25(1):67-72. PubMed PMID: 7811059.

[5] Moeremans M, De Raeymaeker M, Daneels G, De Brabander M, Aerts F, Janssen C, Andries K. Study of the parameters of binding of R 61837 to human rhinovirus 9 and immunobiochemical evidence of capsid-stabilizing activity of the compound. Antimicrob Agents Chemother. 1992 Feb;36(2):417-24. PubMed PMID: 1318682; PubMed Central PMCID: PMC188450.

6: Andries K, Dewindt B, Snoeks J, Willebrords R. Lack of quantitative correlation between inhibition of replication of rhinoviruses by an antiviral drug and their stabilization. Arch Virol. 1989;106(1-2):51-61. PubMed PMID: 2548460.7: Kim KH, Willingmann P, Gong ZX, Kremer MJ, Chapman MS, Minor I, Oliveira MA, Rossmann MG, Andries K, Diana GD, et al. A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A. J Mol Biol. 1993 Mar 5;230(1):206-27. PubMed PMID: 8383771.8: Oren DA, Zhang A, Nesvadba H, Rosenwirth B, Arnold E. Synthesis and activity of piperazine-containing antirhinoviral agents and crystal structure of SDZ 880-061 bound to human rhinovirus 14. J Mol Biol. 1996 May 31;259(1):120-34. PubMed PMID: 8648640.9: Dearden C, al-Nakib W, Andries K, Woestenborghs R, Tyrrell DA. Drug resistant rhinoviruses from the nose of experimentally treated volunteers. Arch Virol. 1989;109(1-2):71-81. PubMed PMID: 2558631.10: al-Nakib W, Higgins PG, Barrow GI, Tyrrell DA, Andries K, Vanden Bussche G, Taylor N, Janssen PA. Suppression of colds in human volunteers challenged with rhinovirus by a new synthetic drug (R61837). Antimicrob Agents Chemother. 1989 Apr;33(4):522-5. PubMed PMID: 2543283; PubMed Central PMCID: PMC172472.

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