78668-34-5|Pyclen|3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene|-范德生物科技公司

Pyclen

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names：
3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene
CAS号：
78668-34-5
MDL Number：
MF(分子式)： C11H18N4 MW(分子量)： 206.29
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene
英文别名	Pyclen;
CAS号	78668-34-5
SMILES	C1(CNCCNCCNC2)=NC2=CC=C1
Inchi	InChI=1S/C11H18N4/c1-2-10-8-13-6-4-12-5-7-14-9-11(3-1)15-10/h1-3,12-14H,4-9H2
InchiKey	LNMUPMQUMCDOKO-UHFFFAOYSA-N
分子式 Formula	C11H18N4
分子量 Molecular Weight	206.29
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Pyclen(CAS:78668-34-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Pyclen is an inhibitor of cell death induced by oxidative stress and inhibitor of AB1-40 aggregation induced by Cu2+ ion. It is capable of both preventing and disrupting Cu(2+) induced AB(1-40) aggregation.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Le Fur M, Beyler M, Lepareur N, Fougère O, Platas-Iglesias C, Rousseaux O, Tripier R. Pyclen Tri-n-butylphosphonate Ester as Potential Chelator for Targeted Radiotherapy: From Yttrium(III) Complexation to (90)Y Radiolabeling. Inorg Chem. 2016 Aug 15;55(16):8003-12. doi: 10.1021/acs.inorgchem.6b01135. Epub 2016 Aug 3. PubMed PMID: 27486673.

[2]Lincoln KM, Gonzalez P, Richardson TE, Julovich DA, Saunders R, Simpkins JW, Green KN. A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders. Chem Commun (Camb). 2013 Apr 4;49(26):2712-4. doi: 10.1039/c2cc36808k. PubMed PMID: 23437435; PubMed Central PMCID: PMC4446701.

[3] Lincoln KM, Richardson TE, Rutter L, Gonzalez P, Simpkins JW, Green KN. An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation. ACS Chem Neurosci. 2012 Nov 21;3(11):919-27. doi: 10.1021/cn300060v. Epub 2012 Aug 31. PubMed PMID: 23173072; PubMed Central PMCID: PMC3503443.

[4] Lincoln KM, Offutt ME, Hayden TD, Saunders RE, Green KN. Structural, spectral, and electrochemical properties of nickel(II), copper(II), and zinc(II) complexes containing 12-membered pyridine- and pyridol-based tetra-aza macrocycles. Inorg Chem. 2014 Feb 3;53(3):1406-16. doi: 10.1021/ic402119s. Epub 2014 Jan 17. PubMed PMID: 24437677.

[5] Le Fur M, Beyler M, Molnár E, Fougère O, Esteban-Gómez D, Tircsó G, Platas-Iglesias C, Lepareur N, Rousseaux O, Tripier R. The role of the capping bond effect on pyclen (nat)Y(3+)/(90)Y(3+) chelates: full control of the regiospecific N-functionalization makes the difference. Chem Commun (Camb). 2017 Aug 24;53(69):9534-9537. doi: 10.1039/c7cc05088g. PubMed PMID: 28808725.

6: Le Fur M, Beyler M, Molnár E, Fougère O, Esteban-Gómez D, Tircsó G, Platas-Iglesias C, Lepareur N, Rousseaux O, Tripier R. Stable and Inert Yttrium(III) Complexes with Pyclen-Based Ligands Bearing Pendant Picolinate Arms: Toward New Pharmaceuticals for β-Radiotherapy. Inorg Chem. 2018 Feb 19;57(4):2051-2063. doi: 10.1021/acs.inorgchem.7b02953. Epub 2018 Feb 5. PubMed PMID: 29400452.7: Le Fur M, Molnár E, Beyler M, Fougère O, Esteban-Gómez D, Rousseaux O, Tripier R, Tircsó G, Platas-Iglesias C. Expanding the Family of Pyclen-Based Ligands Bearing Pendant Picolinate Arms for Lanthanide Complexation. Inorg Chem. 2018 Jun 18;57(12):6932-6945. doi: 10.1021/acs.inorgchem.8b00598. Epub 2018 May 30. PubMed PMID: 29846067.8: Hamon N, Galland M, Le Fur M, Roux A, Duperray A, Grichine A, Andraud C, Le Guennic B, Beyler M, Maury O, Tripier R. Combining a pyclen framework with conjugated antenna for the design of europium and samarium luminescent bioprobes. Chem Commun (Camb). 2018 Jun 12;54(48):6173-6176. doi: 10.1039/c8cc02035c. PubMed PMID: 29845153.9: Le Fur M, Molnár E, Beyler M, Kálmán FK, Fougère O, Esteban-Gómez D, Rousseaux O, Tripier R, Tircsó G, Platas-Iglesias C. A Coordination Chemistry Approach to Fine-Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications. Chemistry. 2018 Mar 2;24(13):3127-3131. doi: 10.1002/chem.201705528. Epub 2018 Feb 6. PubMed PMID: 29243854.

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