32781-79-6|Lorazepam glucuronide|(2S,3S,4S,5R,6S)-6-((7-chloro-5-(2-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid|-范德生物科技公司

Lorazepam glucuronide

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names：
(2S,3S,4S,5R,6S)-6-((7-chloro-5-(2-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
CAS号：
32781-79-6
MDL Number：
MF(分子式)： C21H18Cl2N2O8 MW(分子量)： 497.28
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Lorazepam glucuronide
英文别名	Lorazepam glucuronide;
CAS号	32781-79-6
SMILES	O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2C(NC3=CC=C(Cl)C=C3C(C4=CC=CC=C4Cl)=N2)=O
Inchi	InChI=1S/C21H18Cl2N2O8/c22-8-5-6-12-10(7-8)13(9-3-1-2-4-11(9)23)25-19(18(29)24-12)33-21-16(28)14(26)15(27)17(32-21)20(30)31/h1-7,14-17,19,21,26-28H,(H,24,29)(H,30,31)/t14-,15-,16+,17-,19?,21-/m0/s1
InchiKey	IWOJSSFCRQKNKN-IFBJMGMISA-N
分子式 Formula	C21H18Cl2N2O8
分子量 Molecular Weight	497.28
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lorazepam glucuronide(CAS:32781-79-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lorazepam glucuronide is discontinued (DEA controlled substance). This product belongs to the family of Glucuronic Acid Derivatives. These are compounds containing a glucuronic acid moeity (or a derivative), which consists of a glucose moiety with the C6 carbon oxidized to a carboxylic acid.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Goucher E, Kicman A, Smith N, Jickells S. The detection and quantification of lorazepam and its 3-O-glucuronide in fingerprint deposits by LC-MS/MS. J Sep Sci. 2009 Jul;32(13):2266-72. doi: 10.1002/jssc.200900097. PubMed PMID: 19569106.

[2]Dou C, Bournique JS, Zinda MK, Gnezda M, McNally AJ, Salamone SJ. Comparison of the rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and tamazepam-glucuronide catalyzed by E. coli beta-D-glucuronidase using the on-line benzodiazepine screening immunoassay on the Roche/Hitachi 917 analyzer. J Forensic Sci. 2001 Mar;46(2):335-40. PubMed PMID: 11305436.

[3] Papini O, Bertucci C, da Cunha SP, Dos Santos NA, Lanchote VL. Quantitative assay of lorazepam and its metabolite glucuronide by reverse-phase liquid chromatography-tandem mass spectrometry in human plasma and urine samples. J Pharm Biomed Anal. 2006 Feb 13;40(2):389-96. Epub 2005 Oct 21. PubMed PMID: 16243469.

[4] Herman RJ, Chaudhary A. In vitro binding of lorazepam and lorazepam glucuronide to cholestyramine, colestipol, and activated charcoal. Pharm Res. 1991 Apr;8(4):538-40. PubMed PMID: 1871054.

[5] Chaudhary A, Lane RA, Woo D, Herman RJ. Multiple-dose lorazepam kinetics: shuttling of lorazepam glucuronide between the circulation and the gut during day- and night-time dosing intervals in response to feeding. J Pharmacol Exp Ther. 1993 Dec;267(3):1034-8. PubMed PMID: 8263762.

6: O'Neal CL, Poklis A. Commentary on: Dou C, Bournique J, Zinda M, Gnezda M, Nally A, Salamone S. Comparison of rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and temazepam-glucuronide catalyzed by E. coli beta-glucuronidase using the on-line benzodiazepine screening immunoassay on the Roche/Hitachi 917 analyzer. J Forensic Sci. 2002 Mar;47(2):427-8. PubMed PMID: 11908630.7: Schillings RT, Sisenwine SF, Schwartz MH, Ruelius HW. Lorazepam: glucuronide formation in the cat. Drug Metab Dispos. 1975 Mar-Apr;3(2):85-8. PubMed PMID: 236163.8: Verbeeck R, Tjandramaga TB, Verberckmoes R, De Schepper PJ. Biotransformation and excretion of lorazepam in patients with chronic renal failure. Br J Clin Pharmacol. 1976 Dec;3(6):1033-9. PubMed PMID: 22216526; PubMed Central PMCID: PMC1428960.9: Greenblatt DJ, Franke K, Shader RI. Analysis of lorazepam and its glucuronide metabolite by electron-capture gas--liquid chromatography. Use in pharmacokinetic studies of lorazepam. J Chromatogr. 1978 Sep 1;146(2):311-20. PubMed PMID: 29907.10: Morrison G, Chiang ST, Koepke HH, Walker BR. Effect of renal impairment and hemodialysis on lorazepam kinetics. Clin Pharmacol Ther. 1984 May;35(5):646-52. PubMed PMID: 6713774.1

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