246018-80-4|Lobeline, (+)-|2-((2S,6R)-6-((R)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one|-范德生物科技公司

Lobeline, (+)-

NMR下载 COA and HPLC MSDS下载
names：
2-((2S,6R)-6-((R)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one
CAS号：
246018-80-4
MDL Number：
MF(分子式)： C22H27NO2 MW(分子量)： 337.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lobeline, (+)-
英文别名	Lobeline, (+)-; (+)-Lobeline;
CAS号	246018-80-4
SMILES	CN1[C@H](CC(C2=CC=CC=C2)=O)CCC[C@@H]1C[C@@H](O)C3=CC=CC=C3
Inchi	InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m1/s1
InchiKey	MXYUKLILVYORSK-QHAWAJNXSA-N
分子式 Formula	C22H27NO2
分子量 Molecular Weight	337.46
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lobeline, (+)-(CAS:246018-80-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lobeline, (+)- is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Dwoskin LP, Crooks PA. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochem Pharmacol. 2002 Jan 15;63(2):89-98. Review. PubMed PMID: 11841781.

[2]Miller DK, Crooks PA, Zheng G, Grinevich VP, Norrholm SD, Dwoskin LP. Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters. J Pharmacol Exp Ther. 2004 Sep;310(3):1035-45. Epub 2004 Apr 30. PubMed PMID: 15121762.

[3] Reavill C, Walther B, Stolerman IP, Testa B. Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology. 1990 Jul;29(7):619-24. PubMed PMID: 2385332.

[4] Raj H, Singh VK, Anand A, Paintal AS. Sensory origin of lobeline-induced sensations: a correlative study in man and cat. J Physiol. 1995 Jan 1;482 ( Pt 1):235-46. PubMed PMID: 7730986; PubMed Central PMCID: PMC1157767.

[5] Zheng G, Dwoskin LP, Deaciuc AG, Norrholm SD, Crooks PA. Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter. J Med Chem. 2005 Aug 25;48(17):5551-60. PubMed PMID: 16107155; PubMed Central PMCID: PMC3617589.

6: Marlin DJ, Roberts CA, Schroter RC, Lekeux P. Respiratory responses of mature horses to intravenous lobeline bolus. Equine Vet J. 2000 May;32(3):200-7. PubMed PMID: 10836474.7: Eyerman DJ, Yamamoto BK. Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum. J Pharmacol Exp Ther. 2005 Jan;312(1):160-9. Epub 2004 Aug 26. PubMed PMID: 15331654.8: Lim DY, Kim YS, Miwa S. Influence of lobeline on catecholamine release from the isolated perfused rat adrenal gland. Auton Neurosci. 2004 Jan 30;110(1):27-35. PubMed PMID: 14766322.9: Wang JJ, Liu SM, Chen R, Li L, Guo XS, Xue B, Hu WC. A novel effect of lobeline on vascular smooth muscle cell: inhibition of proliferation induced by endothelin-1. Pharmazie. 2007 Aug;62(8):620-4. PubMed PMID: 17867559.10: Ma Y, Wink M. Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells. Phytomedicine. 2008 Sep;15(9):754-8. doi: 10.1016/j.phymed.2007.11.028. Epub 2008 Jan 28. PubMed PMID: 18222670.1

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