6493-06-7|(±)-Lisofylline|(±)-Lisofylline, Anti-inflammatory agent|-范德生物科技公司

(±)-Lisofylline

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names：
(±)-Lisofylline, Anti-inflammatory agent
CAS号：
6493-06-7
MDL Number：
MF(分子式)： C13H20N4O3 MW(分子量)： 280.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(±)-Lisofylline(6493-06-7);Lisofylline (raceimic)
英文别名	(±)-Lisofylline, Anti-inflammatory agent(6493-06-7);LSF;Lisofylline;CT 1501R;ProTec;
CAS号	6493-06-7
SMILES	O=C(N1CCCCC(O)C)N(C)C2=C(N(C)C=N2)C1=O
Inchi	InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
InchiKey	NSMXQKNUPPXBRG-UHFFFAOYSA-N
分子式 Formula	C13H20N4O3
分子量 Molecular Weight	280.33
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lisofylline (raceimic)(CAS:6493-06-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lisofylline, also known as LSF, improves cellular mitochondrial function and blocks interleukin-12 (IL-12) signaling and STAT-4 activation in target cells and tissues. IL-12 and STAT-4 activation are important pathways linked to inflammation and autoimmune damage to insulin producing cells. Therefore, LSF and related analogs could provide a new therapeutic approach to prevent or reverse type 1 diabetes.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Jung HS, Kaplan LJ, Park PK. Reviewing the studies of the National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network: outcomes and clinical findings. Curr Probl Surg. 2013 Oct;50(10):451-62. doi: 10.1067/j.cpsurg.2013.08.009. Review. PubMed PMID: 24156843.

[2]Jain R, DalNogare A. Pharmacological therapy for acute respiratory distress syndrome. Mayo Clin Proc. 2006 Feb;81(2):205-12. Review. PubMed PMID: 16471076.

[3] Yang Z, Chen M, Nadler JL. Lisofylline: a potential lead for the treatment of diabetes. Biochem Pharmacol. 2005 Jan 1;69(1):1-5. Review. PubMed PMID: 15588708.

[4] Wiedemann HP, Arroliga AC, Komara JJ Jr. Emerging systemic pharmacologic approaches in acute respiratory distress syndrome. Respir Care Clin N Am. 2003 Dec;9(4):419-35. Review. PubMed PMID: 14984064.

[5] Bhandari V. Developmental differences in the role of interleukins in hyperoxic lung injury in animal models. Front Biosci. 2002 Jul 1;7:d1624-33. Epub 2002 Jul 1. Review. PubMed PMID: 12108429.

6: Sturm A, Dignass AU. Modulation of gastrointestinal wound repair and inflammation by phospholipids. Biochim Biophys Acta. 2002 May 23;1582(1-3):282-8. Review. PubMed PMID: 12069839.7: Bright JJ, Sriram S. Immunotherapy of inflammatory demyelinating diseases of the central nervous system. Immunol Res. 2001;23(2-3):245-52. Review. PubMed PMID: 11444389.8: Nemunaitis J. Recombinant hematopoietic growth factors in bone marrow transplantation. Cancer Treat Res. 1995;7

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