65009-35-0|Lidamidine Hydrochloride|1-(2,6-Dimethylphenyl)-3-(imino(methylamino)methyl)uronium chloride|-范德生物科技公司

Lidamidine Hydrochloride

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names：
1-(2,6-Dimethylphenyl)-3-(imino(methylamino)methyl)uronium chloride
CAS号：
65009-35-0
MDL Number：
MF(分子式)： C11H17ClN4O MW(分子量)： 256.734
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Lidamidine Hydrochloride
英文别名	Lidamidine Hydrochloride; WHR-1142A; WHR 1142A; WHR1142A; Lidaral
CAS号	65009-35-0
Inchi	InChI=1S/C11H16N4O.ClH/c1-7-5-4-6-8(2)9(7)14-11(16)15-10(12)13-3;/h4-6H,1-3H3,(H4,12,13,14,15,16);1H
InchiKey	INMBONSHXVMDSX-UHFFFAOYSA-N
分子式 Formula	C11H17ClN4O
分子量 Molecular Weight	256.734
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lidamidine Hydrochloride(CAS:65009-35-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lidamidine Hydrochloride, also known as WHR-1142A and Lidaral, is an alpha2-adrenergic receptor agonist that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction. Lidamidine hydrochloride is used to treat diarrhoea and other gastrointestinal disorders.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Eaker EY, Bixler GB, Mathias JR. WHR 1049, a potent metabolite of lidamidine, has antidiarrheal and antimotility effects on the small intestine in rats. J Pharmacol Exp Ther. 1988 Aug;246(2):786-9. PubMed PMID: 3404458.

[2]Wienbeck M, Bohn M. Different actions of 2 antidiarrheal agents, lidamidine and loperamide, on motility of the isolated cat colon muscle. Z Gastroenterol. 1985 Apr;23(4):175-82. PubMed PMID: 4060808.

[3] Awad RA, Llorens F, Camelo AL, Sánchez M. A randomised double-blind placebo-controlled trial of lidamidine HCL in irritable bowel syndrome. Acta Gastroenterol Latinoam. 2000;30(3):169-75. PubMed PMID: 10975022.

[4] Bleakman D, Naftalin RJ. Prevention of guanine nucleotide-induced reductions in muscarinic agonist binding to rabbit ileal submucosal membranes by lidamidine and tetracaine. Naunyn Schmiedebergs Arch Pharmacol. 1988 Apr;337(4):366-72. PubMed PMID: 2900471.

[5] Sninsky CA, Davis RH, Clench MH, Thomas KD, Mathias JR. Effect of lidamidine hydrochloride and loperamide on gastric emptying and transit of the small intestine. A double-blind study. Gastroenterology. 1986 Jan;90(1):68-73. PubMed PMID: 3940258.

6: Durbin T, Rosenthal L, McArthur K, Anderson D, Dharmsathaphorn K. Clonidine and lidamidine (WHR-1142) stimulate sodium and chloride absorption in the rabbit intestine. Gastroenterology. 1982 Jun;82(6):1352-8. PubMed PMID: 6121738.7: Rodríguez Magallán A, Valadéz Velázquez T, Llorens Torres F, Sánchez Torres MI. [Treatment of irritable colon with lidamidine and support psychotherapy]. Rev Gastroenterol Mex. 1997 Jan-Mar;62(1):7-13. Spanish. PubMed PMID: 9190662.8: Decktor DL, Pendleton RG, Ensslen ME, Davis MM. Lidamidine inhibits intrinsic contractile patterns of the rat proximal colon. Eur J Pharmacol. 1987 Nov 10;143(2):213-9. PubMed PMID: 2891549.9: McArthur KE, Anderson DS, Durbin TE, Orloff MJ, Dharmsathaphorn K. Clonidine and lidamidine to inhibit watery diarrhea in a patient with lung cancer. Ann Intern Med. 1982 Mar;96(3):323-5. PubMed PMID: 7059095.10: Krebs JB, Mir GN. Spasmolytic effect of lidamidine on uterine smooth muscle. Arzneimittelforschung. 1981;31(8):1251-4. PubMed PMID: 6945863.1

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