1703-31-7|LG 50042|2,6-dimethoxy-4-(morpholine-4-carbonyl)phenyl ethyl carbonate|-范德生物科技公司

LG 50042

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names：
2,6-dimethoxy-4-(morpholine-4-carbonyl)phenyl ethyl carbonate
CAS号：
1703-31-7
MDL Number：
MF(分子式)： C16H21NO7 MW(分子量)： 339.34
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	LG 50042
英文别名	LG 50042; LG-50042; LG50042; LG 50,042; LG-50,042; LG50,042;
CAS号	1703-31-7
Inchi	InChI=1S/C16H21NO7/c1-4-23-16(19)24-14-12(20-2)9-11(10-13(14)21-3)15(18)17-5-7-22-8-6-17/h9-10H,4-8H2,1-3H3
InchiKey	SFVJZJHVCCHUGR-UHFFFAOYSA-N
分子式 Formula	C16H21NO7
分子量 Molecular Weight	339.34
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	LG 50042(CAS:1703-31-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	LG 50042 is a bioactive chemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Andreassen KV, Feigh M, Hjuler ST, Gydesen S, Henriksen JE, Beck-Nielsen H, Christiansen C, Karsdal MA, Henriksen K. A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats. Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E24-33. doi: 10.1152/ajpendo.00121.2014. Epub 2014 May 6. PubMed PMID: 24801386.

[2]Hjuler ST, Andreassen KV, Gydesen S, Karsdal MA, Henriksen K. KBP-042 improves bodyweight and glucose homeostasis with indices of increased insulin sensitivity irrespective of route of administration. Eur J Pharmacol. 2015 Sep 5;76

2:229-38. doi: 10.1016/j.ejphar.2015.05.051. Epub 2015 May 28. PubMed PMID: 26027795.

[4]Arakawa K, Maehara S, Yuge N, Ishikawa M, Miyazaki Y, Naba H, Kato Y, Nakao K. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM-042 [(E)-4-(2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-6-(pyrrolidi n-1-yl)pyrimidin-4-yl)morpholine] in rats: potential for the treatment of schizophrenia. Pharmacol Res Perspect. 2016 Jun 10;4(4):e00241. doi: 10.1002/prp2.241. eCollection 2016 Aug. PubMed PMID: 28116094; PubMed Central PMCID: PMC5242175.

[5] Miyake T, Honma Y, Urano T, Kato N, Suzumiya J. Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells. Int J Oncol. 2015 Jul;47(1):315-24. doi: 10.3892/ijo.2015.2979. Epub 2015 Apr 30. PubMed PMID: 25936828.

5: Hjuler ST, Gydesen S, Andreassen KV, Pedersen SL, Hellgren LI, Karsdal MA, Henriksen K. The dual amylin- and calcitonin-receptor agonist KBP-042 increases insulin sensitivity and induces weight loss in rats with obesity. Obesity (Silver Spring). 2016 Aug;24(8):1712-22. doi: 10.1002/oby.21563. Epub 2016 Jun 14. PubMed PMID: 27296301.

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