4792-18-1|Levoxadrol|(2R)-2-[(4R)-2,2-Diphenyl-1,3-dioxolan-4-yl]piperidine|-范德生物科技公司

Levoxadrol

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names：
(2R)-2-[(4R)-2,2-Diphenyl-1,3-dioxolan-4-yl]piperidine
CAS号：
4792-18-1
MDL Number：
MF(分子式)： C20H23NO2 MW(分子量)： 309.4
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Levoxadrol
英文别名	Levoxadrol;
CAS号	4792-18-1
SMILES	[C@@H]1([C@H]2OC(C3=CC=CC=C3)(C4=CC=CC=C4)OC2)NCCCC1
Inchi	InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2/t18-,19+/m1/s1
InchiKey	HGKAMARNFGKMLC-MOPGFXCFSA-N
分子式 Formula	C20H23NO2
分子量 Molecular Weight	309.4
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Levoxadrol(CAS:4792-18-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Levoxadrol is an inhibitor of the phencyclidine (PCP) receptor. It acts by producing morphine-like antinociception and sedation, relieving pain without the loss of consciousness.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Grant KA, Colombo G, Grant J, Rogawski MA. Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists. Neuropharmacology. 1996;35(12):1709-19. PubMed PMID: 9076750.

[2]Pechnick RN, Poland RE. Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors. Eur J Pharmacol. 1994 Sep 22;263(1-2):115-20. PubMed PMID: 7821343.

[3] Jamieson GA, Agrawal AK, Greco NJ, Tenner TE Jr, Jones GD, Rice KC, Jacobson AE, White JG, Tandon NN. Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline. Biochem J. 1992 Jul 1;285 ( Pt 1):35-9. PubMed PMID: 1322125; PubMed Central PMCID: PMC1132740.

[4] Domino EF. Chemical dissociation of human awareness: focus on non-competitive NMDA receptor antagonists. J Psychopharmacol. 1992 Jan;6(3):418-24. doi: 10.1177/026988119200600312. PubMed PMID: 22291389.

[5] Haring R, Pellegrini-Giampietro DE, Zukin SR, Zukin RS, Scheideler MA. High efficiency reconstitution of a phencyclidine/MK-801 receptor binding site solubilized from rat forebrain membranes. Mol Pharmacol. 1991 Nov;40(5):666-73. PubMed PMID: 1658603.

6: Brog JS, Beinfeld MC. Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists involves blockade of the muscarinic cholinergic receptor: a novel dioxadrol-preferring interaction. J Pharmacol Exp Ther. 1990 Sep;254(3):952-6. PubMed PMID: 2203900.7: Mount H, Boksa P, Chaudieu I, Quirion R. Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site. Can J Physiol Pharmacol. 1990 Sep;68(9):1200-6. PubMed PMID: 1980428.8: Allard LR, Brog JS, Viereck JC, Contreras PC, Jacobson AE, Rice KC, Beinfeld MC. Inhibition of potassium-evoked release of cholecystokinin from rat caudate-putamen, cerebral cortex and hippocampus incubated in vitro by phencyclidine and related compounds. Brain Res. 1990 Jul 9;522(2):224-6. PubMed PMID: 2171716.9: ffrench-Mullen JM, Rogawski MA. Interaction of phencyclidine with voltage-dependent potassium channels in cultured rat hippocampal neurons: comparison with block of the NMDA receptor-ionophore complex. J Neurosci. 1989 Nov;9(11):4051-61. PubMed PMID: 2555461.10: Pechnick RN, Wong CA, George R, Thurkauf A, Jacobson AE, Rice KC. Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat. Neuropharmacology. 1989 Aug;28(8):829-35. PubMed PMID: 2674766.1

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