43033-72-3|Levomethadyl acetate HCl|(3S,6S)-6-(dimethylamino)-4,4-diphenylheptan-3-yl acetate hydrochloride|-范德生物科技公司

Levomethadyl acetate HCl

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names：
(3S,6S)-6-(dimethylamino)-4,4-diphenylheptan-3-yl acetate hydrochloride
CAS号：
43033-72-3
MDL Number：
MF(分子式)： C23H32ClNO2 MW(分子量)： 389.96
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Levomethadyl acetate HCl
英文别名	Levomethadyl acetate hydrochloride; L-alpha-Acetylmethadol hydrochloride; MK 790; MK-790; MK790; LAAM;
CAS号	43033-72-3
Inchi	InChI=1S/C23H31NO2.ClH/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21;/h7-16,18,22H,6,17H2,1-5H3;1H/t18-,22-;/m0./s1
InchiKey	UXBPQRGCVJOTNT-COBSGTNCSA-N
分子式 Formula	C23H32ClNO2
分子量 Molecular Weight	389.96
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Levomethadyl acetate HCl(CAS:43033-72-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Levomethadyl acetate HCl is discontinued (DEA controlled substance). This products is a methadone derivative.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Freddi R, Duca P, Gritti I, Mariotti M, Vertemati M. Behavioral and degeneration changes in the basal forebrain systems of aged rats: a quantitative study in the region of the basal forebrain after levo-acetyl-carnitine treatments assessed by Abercrombie estimation. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):419-26. doi: 10.1016/j.pnpbp.2008.12.02[1]Epub 2009 Jan 7. PubMed PMID: 19171177.

[2]Deamer RL, Wilson DR, Clark DS, Prichard JG. Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM). J Addict Dis. 2001;20(4):7-14. Review. PubMed PMID: 11760927.

[3] Borzelleca JF, Egle JL Jr, Harris LS, Belleville JA. Toxicological evaluation of mu-agonists. Part II: Assessment of toxicity following 30 days of repeated oral dosing of male and female rats with levo-alpha-noracetylmethadol HCl (NorLAAM). J Appl Toxicol. 1995 Sep-Oct;15(5):339-55. PubMed PMID: 8666717.

[4] Borzelleca JF, Egle JL Jr, Harris LS, Johnson DN, Terrill JB, Belleville JA. Toxicological evaluation of mu-agonists. Part I: Assessment of toxicity following 30 days of repeated oral dosing of male and female rats with levo-alpha-acetylmethadol HCl (LAAM). J Appl Toxicol. 1994 Nov-Dec;14(6):435-46. PubMed PMID: 7884149.

[5] Thomas BF, Jeffcoat AR, Myers MW, Mathews JM, Cook CE. Determination of l-alpha-acetylmethadol, l-alpha-noracetylmethadol and l-alpha-dinoracetylmethadol in plasma by gas chromatography-mass spectrometry. J Chromatogr B Biomed Appl. 1994 May 13;655(2):201-11. PubMed PMID: 8081466.

6: Rosenkrantz H, Fleischman RW. In vivo carcinogenesis assay of L-alpha-acetylmethadol.HCl in rodents. Fundam Appl Toxicol. 1988 Nov;11(4):626-39. PubMed PMID: 3229587.7: McGillkiard KL, Jones SE, Robertson GE, Olsen GD. Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM). Respir Physiol. 1982 Mar;47(3):299-311. PubMed PMID: 6808626.8: Finlayson MJ, Bellward GD. Effects of perinatal exposure of Wistar rats to l-alpha-acetylmethadol.HCl on hepatic microsomal mixed-function oxidase enzyme activity in the adult. Drug Metab Dispos. 1982 Jan-Feb;10(1):74-6. PubMed PMID: 6124388.

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