73278-54-3|Lamtidine|1-(m-(3-((3-Amino-1-methyl-1H-1,2,4-triazol-5-yl)amino)propoxy)benzyl)piperidine|-范德生物科技公司

Lamtidine

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names：
1-(m-(3-((3-Amino-1-methyl-1H-1,2,4-triazol-5-yl)amino)propoxy)benzyl)piperidine
CAS号：
73278-54-3
MDL Number：
MF(分子式)： C18H28N6O MW(分子量)： 344.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lamtidine
英文别名	AH-22216; AH22216; AH 22216
CAS号	73278-54-3
Inchi	InChI=1S/C18H28N6O/c1-23-18(21-17(19)22-23)20-9-6-12-25-16-8-5-7-15(13-16)14-24-10-3-2-4-11-24/h5,7-8,13H,2-4,6,9-12,14H2,1H3,(H3,19,20,21,22)
InchiKey	NRIGRKAXOLMTSK-UHFFFAOYSA-N
分子式 Formula	C18H28N6O
分子量 Molecular Weight	344.46
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lamtidine(CAS:73278-54-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lamtidine is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Coruzzi G, Adami M, Morini G, Pozzoli C, Cena C, Bertinaria M, Gasco A. Antisecretory and gastroprotective activities of compounds endowed with H2 antagonistic and nitric oxide (NO) donor properties. J Physiol Paris. 2000 Jan-Feb;94(1):5-10. PubMed PMID: 10761682.

[3] Sorba G, Gasco A, Coruzzi G, Adami M, Pozzoli C, Morini G, Bertaccini G. Mixed antisecretory and gastroprotective activities of a new H2-antagonist containing a nitric oxide-donor furoxan moiety. Arzneimittelforschung. 1997 Jul;47(7):849-54. PubMed PMID: 9272244.

[4] Le Gros G, Zhang XM, Parsons PG. Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands. Melanoma Res. 1994 Dec;4(6):359-64. PubMed PMID: 7535606.

[5] Schulze FR, Alisch RA, Buschauer A, Schunack W. [Synthesis and combined H1-/H2 antagonist activity of mepyramine, pheniramine and cyclizine derivatives with cyanoguanidine, urea and nitroethenediamine partial structures]. Arch Pharm (Weinheim). 1994 Jul;327(7):455-62. German. PubMed PMID: 7915515.

6: Orsetti M, Sorba G. Characterization of an accessory binding area in the histamine H2 receptor. Eur J Pharmacol. 1991 Jul 12;207(3):259-65. PubMed PMID: 1680063.7: Büyüktimkin N, Keller F, Schunack W. Gas-liquid chromatographic resolution of some racemic synthons for lamtidine analogous histamine H2-receptor antagonists via diastereomeric amides of (1S)-(-)-camphanic acid. J Chromatogr. 1989 Apr 28;467(2):402-5. PubMed PMID: 2569470.8: Orsetti M. Histamine H2-receptor blocking activity of ranitidine and lamtidine analogues containing aminomethyl-substituted aliphatic systems. Agents Actions. 1988 Dec;25(3-4):291-5. PubMed PMID: 2905866.9: Bonjean VJ, Schunack W. [Alkyl- and alkoxy-substituted lamtidine analogs: synthesis and H2-antagonistic activity. 38. H2-antihistaminics]. Arzneimittelforschung. 1988 Apr;38(4):501-7. German. PubMed PMID: 2900010.10: Orsetti M, Sorba G. Pharmacological profile of new histamine H2-receptor antagonists related to cimetidine, ranitidine and lamtidine. J Pharm Pharmacol. 1988 Jan;40(1):31-4. PubMed PMID: 2896770.1

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