38455-85-5|l-alpha-Noracetylmethadol|6-(methylamino)-4,4-diphenylheptan-3-ol|-范德生物科技公司

l-alpha-Noracetylmethadol

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names：
6-(methylamino)-4,4-diphenylheptan-3-ol
CAS号：
38455-85-5
MDL Number：
MF(分子式)： C20H27NO MW(分子量)： 297.44
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	l-alpha-Noracetylmethadol
英文别名	l-alpha-Noracetylmethadol; alpha-Noracetylmethadol, l;
CAS号	38455-85-5
Inchi	InChI=1S/C20H27NO/c1-4-19(22)20(15-16(2)21-3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21-22H,4,15H2,1-3H3
InchiKey	KYHAUJGXNUJCTC-UHFFFAOYSA-N
分子式 Formula	C20H27NO
分子量 Molecular Weight	297.44
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	l-alpha-Noracetylmethadol(CAS:38455-85-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	l-alpha-Noracetylmethadol is discontinued (DEA controlled substance).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Newcombe DAL, Somogyi AA, Bochner F, White JM. Impaired psychomotor function and plasma methadone and levo-alpha-acetylmethadol (LAAM) concentrations in opioid-substitution patients. Exp Clin Psychopharmacol. 2017 Jun;25(3):223-233. doi: 10.1037/pha0000114. Epub 2017 Apr 17. PubMed PMID: 28414496.

[2]Schrott LM, Sparber SB. Suppressed fever and hypersensitivity responses in chicks prenatally exposed to opiates. Brain Behav Immun. 2004 Nov;18(6):515-25. PubMed PMID: 15331122.

[3] Deshmukh SV, Nanovskaya TN, Hankins GD, Ahmed MS. N-demethylation of levo-alpha-acetylmethadol by human placental aromatase. Biochem Pharmacol. 2004 Mar 1;67(5):885-92. PubMed PMID: 15104241.

[4] Nanovskaya TN, Deshmukh SV, Miles R, Burmaster S, Ahmed MS. Transfer of L-alpha-acetylmethadol (LAAM) and L-alpha-acetyl-N-normethadol (norLAAM) by the perfused human placental lobule. J Pharmacol Exp Ther. 2003 Jul;306(1):205-12. Epub 2003 Apr 3. PubMed PMID: 12676878.

[5] Kang J, Chen XL, Wang H, Rampe D. Interactions of the narcotic l-alpha-acetylmethadol with human cardiac K+ channels. Eur J Pharmacol. 2003 Jan 1;458(1-2):25-9. PubMed PMID: 12498903.

6: Huang W, Bemis PA, Slawson MH, Moody DE. Determination of l-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and tandem mass spectrometry. J Pharm Sci. 2003 Jan;92(1):10-20. PubMed PMID: 12486677.7: Schrott LM, Baumgart MI, Zhang X, Sparber SB. Prenatal opiate withdrawal activates the chick embryo hypothalamic pituitary-adrenal axis and dilates vitelline blood vessels via serotonin(2) receptors. J Pharmacol Exp Ther. 2002 Oct;303(1):257-64. PubMed PMID: 12235259.8: Neff JA, Moody DE. Differential N-demethylation of l-alpha-acetylmethadol (LAAM) and norLAAM by cytochrome P450s 2B6, 2C18, and 3A4. Biochem Biophys Res Commun. 2001 Jun 15;284(3):751-6. PubMed PMID: 11396966.9: Oda Y, Kharasch ED. Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. J Pharmacol Exp Ther. 2001 Apr;297(1):410-22. PubMed PMID: 11259570.10: O'Connor PG, Fiellin DA. Pharmacologic treatment of heroin-dependent patients. Ann Intern Med. 2000 Jul 4;133(1):40-54. Review. PubMed PMID: 10877739.1

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