156511-34-1|L 739749|methyl (2R)-2-((2-amino-3-mercaptopropyl)amino)-2-(N-(((S)-3-methylpentyl)oxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoate|-范德生物科技公司

L 739749

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names：
methyl (2R)-2-((2-amino-3-mercaptopropyl)amino)-2-(N-(((S)-3-methylpentyl)oxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoate
CAS号：
156511-34-1
MDL Number：
MF(分子式)： C24H41N3O6S2 MW(分子量)： 531.72
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L 739749
英文别名	L 739749; L-739749; L739749; L-739,749; L 739,749; L739,749;
CAS号	156511-34-1
Inchi	InChI=1S/C24H41N3O6S2/c1-5-19(2)13-15-33-27(22(28)12-11-20-9-7-6-8-10-20)24(23(29)32-3,14-16-35(4,30)31)26-17-21(25)18-34/h6-10,19,21,26,34H,5,11-18,25H2,1-4H3/t19-,21?,24+/m0/s1
InchiKey	NMDIHBJSLHSAMQ-LDEFDFMYSA-N
分子式 Formula	C24H41N3O6S2
分子量 Molecular Weight	531.72
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L 739749(CAS:156511-34-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L 739749 is a CAAX peptidomimetic; a farnesyl-protein transferase inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Xu Y, Chiamvimonvat N, Vázquez AE, Akunuru S, Ratner N, Yamoah EN. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. J Neurosci. 2002 Nov 1;22(21):9194-202. PubMed PMID: 12417644.

[3] Bulus NM, Sheng HM, Sizemore N, Oldham SM, Barnett JV, Coffey RJ, Beauchamp DR, Barnard JA. Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling. Neoplasia. 2000 Jul-Aug;2(4):357-64. PubMed PMID: 11005570; PubMed Central PMCID: PMC1550294.

[4] Emanuel PD, Snyder RC, Wiley T, Gopurala B, Castleberry RP. Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors. Blood. 2000 Jan 15;95(2):639-45. PubMed PMID: 10627474.

[5] Lebowitz PF, Casey PJ, Prendergast GC, Thissen JA. Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. J Biol Chem. 1997 Jun 20;272(25):15591-4. PubMed PMID: 9188444.

6: Lebowitz PF, Sakamuro D, Prendergast GC. Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment. Cancer Res. 1997 Feb 15;57(4):708-13. PubMed PMID: 9044849.7: Kim HA, Ling B, Ratner N. Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase. Mol Cell Biol. 1997 Feb;17(2):862-72. PubMed PMID: 9001241; PubMed Central PMCID: PMC231813.8: Fukazawa H, Nakano S, Mizuno S, Uehara Y. Inhibitors of anchorage-independent growth affect the growth of transformed cells on poly(2-hydroxyethyl methacrylate)-coated surfaces. Int J Cancer. 1996 Sep 17;67(6):876-82. PubMed PMID: 8824562.9: Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors. Cancer Res. 1996 Jun 1;56(11):2626-32. PubMed PMID: 8653708.10: James G, Goldstein JL, Brown MS. Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4454-8. PubMed PMID: 8633088; PubMed Central PMCID: PMC39559.1

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