135525-71-2|L-696229|3-(2-(Benzoxazol-2-yl)ethyl)-5-ethyl-6-methylpyridin-2(1H)-one|-范德生物科技公司

L-696229

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names：
3-(2-(Benzoxazol-2-yl)ethyl)-5-ethyl-6-methylpyridin-2(1H)-one
CAS号：
135525-71-2
MDL Number：
MF(分子式)： C17H18N2O2 MW(分子量)： 282.343
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L-696229
英文别名	L-696229; L 696229; L696229; L-696,229; L 696,229; L696,229.
CAS号	135525-71-2
Inchi	InChI=1S/C17H18N2O2/c1-3-12-10-13(17(20)18-11(12)2)8-9-16-19-14-6-4-5-7-15(14)21-16/h4-7,10H,3,8-9H2,1-2H3,(H,18,20)
InchiKey	MHUVLRNBDLFMHQ-UHFFFAOYSA-N
分子式 Formula	C17H18N2O2
分子量 Molecular Weight	282.343
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L-696229(CAS:135525-71-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L-696229 is a specific inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity that possesses antiviral activity in cell culture. L-696,229 inhibited RT activity in a mutually exclusive manner with respect to either phosphonoformate or azidothymidine triphosphate and was a weak partial inhibitor of the RNase H activity associated with HIV-1 RT. L-696,229 inhibited the spread of HIV-1 infection in cell cultures with all cell types and viral isolates tested, including human peripheral blood mononuclear cells and a virus isolate resistant to azidothymidine.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lee LL, Herold ML, Zacchei AG. High-performance liquid chromatographic method for the determination of an HIV-1 non-nucleoside reverse transcriptase inhibitor (L-696,229) in plasma samples from animals. J Chromatogr B Biomed Appl. 1996 Oct 25;685(2):323-8. PubMed PMID: 8953174.

[2]Prueksaritanont T, Dwyer LM, Balani SK, Theoharides AD. In vitro metabolism of L-696,229, an HIV-1 reverse transcriptase inhibitor in rats and humans. Hepatic and extrahepatic metabolism and identification of enzymes involved in the hepatic metabolism. Drug Metab Dispos. 1994 Mar-Apr;22(2):281-8. PubMed PMID: 7516854.

[3] Balani SK, Kauffman LR, Arison BH, Olah TV, Goldman ME, Varga SL, O'Brien JA, Ramjit HG, Rooney CS, Hoffman JM, et al. Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans. Drug Metab Dispos. 1994 Mar-Apr;22(2):200-5. PubMed PMID: 7516852.

[4] Emini EA, Byrnes VW, Condra JH, Schleif WA, Sardana VV. The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors. Arch Virol Suppl. 1994;9:11-7. Review. PubMed PMID: 7518271.

[5] Schleif WA, Murthy KK, Sardana VV, Schneider CL, Byrnes VW, Cobb KE, Roth E, Wolfgang JA, Hoffman JM, Smith AM, et al. Attempted prophylaxis of human immunodeficiency virus type 1 infection in chimpanzees with a nonnucleoside reverse transcriptase inhibitor. AIDS Res Hum Retroviruses. 1994 Jan;10(1):107-10. PubMed PMID: 7514014.

6: Goldman ME, O'Brien JA, Ruffing TL, Schleif WA, Sardana VV, Byrnes VW, Condra JH, Hoffman JM, Emini EA. A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors. Antimicrob Agents Chemother. 1993 May;37(5):947-9. PubMed PMID: 7685996; PubMed Central PMCID: PMC187857.7: Hoffman JM, Smith AM, Rooney CS, Fisher TE, Wai JS, Thomas CM, Bamberger DL, Barnes JL, Williams TM, Jones JH, et al. Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogues. J Med Chem. 1993 Apr 16;36(8):953-66. PubMed PMID: 7683054.8: Carroll SS, Olsen DB, Bennett CD, Gotlib L, Graham DJ, Condra JH, Stern AM, Shafer JA, Kuo LC. Inhibition of HIV-1 reverse transcriptase by pyridinone derivatives. Potency, binding characteristics, and effect of template sequence. J Biol Chem. 1993 Jan 5;268(1):276-81. PubMed PMID: 7677997.9: Woolf EJ, Matuszewski BK. Column-switching high-performance liquid chromatographic determination of a 2-pyridinone-based human immunodeficiency virus type 1 (HIV-1)-specific reverse transcriptase inhibitor in human plasma. Pharm Res. 1993 Jan;10(1):56-60. PubMed PMID: 7679213.10: O'Brien JA, Ostovic D, Schorn TW, Smith SJ, Ruffing TL, Siegl PK, Goldman ME. A rapid bioassay for the determination of non-nucleoside HIV-1 reverse transcriptase inhibitor plasma levels. Life Sci. 1993;52(3):243-9. PubMed PMID: 7678687.1

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