122384-14-9|L 663581|7-chloro-3-(5-isopropyl-1,2,4-oxadiazol-3-yl)-5-methyl-4,5-dihydro-6H-benzo[f]imidazo[1,5-a][1,4]diazepin-6-one|-范德生物科技公司

L 663581

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names：
7-chloro-3-(5-isopropyl-1,2,4-oxadiazol-3-yl)-5-methyl-4,5-dihydro-6H-benzo[f]imidazo[1,5-a][1,4]diazepin-6-one
CAS号：
122384-14-9
MDL Number：
MF(分子式)： C17H16ClN5O2 MW(分子量)： 357.79
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	L 663581
英文别名	L 663581; L-663581; L663581; FG-8205; FG 8205; FG8205;
CAS号	122384-14-9
Inchi	InChI=1S/C17H16ClN5O2/c1-9(2)16-20-15(21-25-16)14-12-7-22(3)17(24)13-10(18)5-4-6-11(13)23(12)8-19-14/h4-6,8-9H,7H2,1-3H3
InchiKey	SEWXZWMBVGJJPG-UHFFFAOYSA-N
分子式 Formula	C17H16ClN5O2
分子量 Molecular Weight	357.79
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L 663581(CAS:122384-14-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L 663581 is a Pprtial agonist at the benzodiazepine receptor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Guscott MR, Cook GP, Bristow LJ. Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: a comparison of benzodiazepine/gamma-aminobutyric acid-A receptor agonists. Behav Pharmacol. 2000 Sep;11(6):495-504. PubMed PMID: 11103915.

[2]Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ. Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. Eur J Pharmacol. 1995 Nov 30;291(3):301-9. PubMed PMID: 8719414.

[3] Jackson A. State-dependent effects of atypical benzodiazepine-receptor agonists. Psychopharmacology (Berl). 1995 Jun;119(4):399-404. PubMed PMID: 7480519.

[4] Lin JH, Chen IW, Lin TH. Blood-brain barrier permeability and in vivo activity of partial agonists of benzodiazepine receptor: a study of L-663,581 and its metabolites in rats. J Pharmacol Exp Ther. 1994 Dec;271(3):1197-202. PubMed PMID: 7996426.

[5] Chen IW, Lin JH. Physiological disposition of L-663,581, a partial agonist of the benzodiazepine receptor, in laboratory animals. Drug Metab Dispos. 1994 Sep-Oct;22(5):693-9. PubMed PMID: 7835219.

6: Stanhope KJ, Roe S, Dawson G, Draper F, Jackson A. Effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid consumption in the rat. Psychopharmacology (Berl). 1993;111(2):185-9. PubMed PMID: 7870950.7: Tricklebank MD, Honoré T, Iversen SD, Kemp JA, Knight AR, Marshall GR, Rupniak NM, Singh L, Tye S, Watjen F, et al. The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist at the benzodiazepine receptor. Br J Pharmacol. 1990 Nov;101(3):753-61. PubMed PMID: 1963808; PubMed Central PMCID: PMC1917729.8: Lin TH, Lin JH. Effects of protein binding and experimental disease states on brain uptake of benzodiazepines in rats. J Pharmacol Exp Ther. 1990 Apr;253(1):45-50. PubMed PMID: 1970363.

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